Human necrotizing vasculitis: immunoglobulins and complement in vessel walls of cutaneous lesions and normal skin.
Human necrotizing vasculitis: immunoglobulins and complement in vessel walls of cutaneous lesions and normal skin.
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人类坏死性血管炎：皮肤病变和正常皮肤血管壁中的免疫球蛋白和补体。
DOI：
10.1111/1523-1747.ep12512411
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
M.F. Mass
中科院分区：
文献类型：
--
作者：
W. Sams;H. Claman;Peter F. Kohler;Rawle M. McIntosh;Peter. Small;M.F. Mass
免疫荧光法检测活动性坏死性血管炎患者临床正常皮肤活检血管壁中免疫球蛋白和C3。在研究的13例患者中，9例有C3，其中6例在血管炎病变活检中有IgM或伊加。在邻近的临床正常皮肤中，7例患者有C3，其中3例也有IgM或伊加。这些研究结果支持的假设，即免疫球蛋白和补体存在于某些患者的血管之前，趋化性的多形核白细胞和由此产生的炎症性紫癜性病变坏死性血管炎的特点。
Immunoglobulins and C3 were detected by immunofluorescence in the blood vessel walls of biopsies of clinically normal skin in patients with active necrotizing vasculitis. Of the 13 patients studied, 9 had C3 and 6 of these had IgM or IgA in biopsies of lesions of vasculitis. In adjacent clinically normal skin, 7 patients had C3 and 3 of these also had IgM or IgA. These findings support the hypothesis that immunoglobulins and complement are present in vessels of some patients prior to chemotaxis of polymorphonuclear leukocytes and the resulting inflammatory purpuric lesions so characteristic of necrotizing vasculitis.