Body fat and fat-free mass and all-cause mortality
Body fat and fat-free mass and all-cause mortality
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DOI：
10.1038/oby.2004.131
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发表时间：
2004-07-01
期刊：
影响因子：
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通讯作者：
Sorensen, TIA
中科院分区：
文献类型：
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作者：
Bigaard, J;Frederiksen, K;Sorensen, TIA
目的：为了研究BMI和全因死亡率之间的关联是否可以被分解为身体脂肪和无脂肪质量（FFM）的相反影响，研究方法和程序：全因死亡率在丹麦的随访研究“饮食，癌症和健康”中进行了研究，从1993年到1997年招募了27,178名男性和29,875名女性，年龄在50到64岁之间。到2001年底，中位随访时间为5.8年，1851人死亡。通过生物电阻抗评估身体组成。考克斯回归模型用于估计体脂质量指数（体脂质量除以身高的平方）、FFM指数（FFM除以身高的平方）和死亡率之间的关系。所有的分析都调整了吸烟习惯。结果：男性和女性表现出类似的协会。经FFM和吸烟校正后，发现身体脂肪质量指数与死亡率之间存在J形关联。男性和女性的上半身脂肪量死亡率比分别为1.12/kg/m2（95%置信区间：1.07，1.18）和1.06/kg/m2（95%置信区间：1.02，1.10）。倒J形协会之间FFM指数和死亡率的趋势趋于平稳的高值FFM.Discussion：我们的研究结果表明，BMI代表关节，但相反的协会体脂肪和FFM与死亡率。高体脂和低FFM都是全因死亡率的独立预测因子。
Objective: To investigate whether the association between BMI and all-cause mortality could be disentangled into opposite effects of body fat and fat-free mass (FFM).Research Methods and Procedures: All-cause mortality was studied in the Danish follow-up study "Diet, Cancer and Health" with 27,178 men and 29,875 women 50 to 64 years old recruited from 1993 to 1997. By the end of year 2001, the median follow-up was 5.8 years, and 1851 had died. Body composition was assessed by bioelectrical impedance. Cox regression models were used to estimate the relationships among body fat mass index (body fat mass divided by height squared), FFM index (FFM divided by height squared), and mortality. All analyses were adjusted for smoking habits.Results: Men and women showed similar associations. J-shaped associations were found between body fat mass index and mortality adjusted for FFM and smoking. The mortality rate ratios in the upper part of body fat mass were 1.12 per kg/m(2) (95% confidence interval: 1.07 , 1.18) in men and 1.06 per kg/m(2) 2 (95% confidence interval: 1.02, 1.10) in women. Reversed J-shaped associations were found be tween FFM index and mortality with a tendency to level off for high values of FFM.Discussion: Our findings suggest that BMI represents joint but opposite associations of body fat and FFM with mortality. Both high body fat and low FFM are independent predictors of all-cause mortality.