Theta activity paradoxically boosts gamma and ripple frequency sensitivity in prefrontal interneurons
Theta activity paradoxically boosts gamma and ripple frequency sensitivity in prefrontal interneurons
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矛盾的是，Theta 活动提高了前额叶中间神经元的伽马频率和纹波频率敏感性
DOI：
10.1073/pnas.2114549118
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Neef, Andreas
中科院分区：
文献类型：
--
作者：
Merino, Ricardo Martins;Leon-Pinzon, Carolina;Stühmer, Walter;Möck, Martin;Staiger, Jochen F.;Wolf, Fred;Neef, Andreas
皮质回路的快速振荡很大程度上取决于 GABA 能中间神经元。然而，哪些中间神经元类型和群体可以驱动不同的皮质节律仍然悬而未决，并且可能取决于大脑状态。在这里，我们测量了前额皮质中不同 GABA 能中间神经元在模拟不同大脑状态的条件下的敏感性。虽然快速尖峰神经元始终表现出 400 Hz 左右的宽带宽，但尖峰频率适应中间神经元的响应特性会随着背景输入的统计数据而变化。缓慢波动的背景活动（典型的睡眠或安静清醒状态）极大地提高了神经元对伽马和纹波频率的敏感性。我们开发了时间分辨动态增益分析，并揭示了快速灵敏度调制，使神经元能够在持续低频振荡的特定阶段周期性地增强伽马振荡和波纹。这种机制预测这些前额叶中间神经元对高频波动非常敏感，尤其是在以慢节奏为特征的大脑状态下，并且对 θ-γ 交叉频率耦合有很大贡献。
Fast oscillations in cortical circuits critically depend on GABAergic interneurons. Which interneuron types and populations can drive different cortical rhythms, however, remains unresolved and may depend on brain state. Here, we measured the sensitivity of different GABAergic interneurons in prefrontal cortex under conditions mimicking distinct brain states. While fast-spiking neurons always exhibited a wide bandwidth of around 400 Hz, the response properties of spike-frequency adapting interneurons switched with the background input’s statistics. Slowly fluctuating background activity, as typical for sleep or quiet wakefulness, dramatically boosted the neurons’ sensitivity to gamma and ripple frequencies. We developed a time-resolved dynamic gain analysis and revealed rapid sensitivity modulations that enable neurons to periodically boost gamma oscillations and ripples during specific phases of ongoing low-frequency oscillations. This mechanism predicts these prefrontal interneurons to be exquisitely sensitive to high-frequency ripples, especially during brain states characterized by slow rhythms, and to contribute substantially to theta-gamma cross-frequency coupling.
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影响因子：
13.6
作者：
Lazarov E;Dannemeyer M;Feulner B;Enderlein J;Gutnick MJ;Wolf F;Neef A
通讯作者：
Neef A
影响因子：
5.3
作者：
Higgs, Matthew H.;Spain, William J.
通讯作者：
Spain, William J.
影响因子：
3.7
作者：
Koendgen, Harold;Giesler, Caroline;Giugliano, Michele
通讯作者：
Giugliano, Michele
影响因子：
2.5
作者：
Geisler, C;Brunel, N;Wang, XJ
通讯作者：
Wang, XJ