EFFECTS OF 6-HYDROXYDOPAMINE LESIONS OF LOCUS COERULEUS ON STARTLE IN RATS
EFFECTS OF 6-HYDROXYDOPAMINE LESIONS OF LOCUS COERULEUS ON STARTLE IN RATS
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DOI：
10.1007/bf00426474
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发表时间：
1981-01-01
影响因子：
3.4
通讯作者：
GEYER, MA
中科院分区：
文献类型：
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作者：
ADAMS, LM;GEYER, MA
为了研究蓝斑上含有去甲肾上腺素（NE）的神经元可能参与了对感觉刺激的行为反应性的调节，我们通过局部注射儿茶酚胺神经毒素6-羟多巴胺对蓝斑进行了双侧化学损伤。组织化学和生化分析均证实了病变特异性清除蓝斑区含NE的细胞体的有效性，并使海马和黑质的NE含量分别降低了45%和69%。在损伤后5天和36天，对大鼠进行了对重复性触觉刺激的惊吓反应测试。在这两天，蓝斑损伤的大鼠在整个刺激系列中表现出持续减少的惊吓反应。此外，受损大鼠表现出更快的反应习惯率，特别是在第一次测试中。讨论了蓝斑对感觉刺激致敏过程的可能影响。
To examine the possible involvement of the norepinephrine (NE) containing neurons of the locus coeruleus in the modulation of behavioral reactivity to sensory stimulation, bilateral chemical lesions of the locus coeruleus were made by local injection of the catecholamine neurotoxin 6-hydroxydopamine. Both histochemical and biochemical analyses confirmed the effectiveness of the lesions in specifically eliminating the NE containing cell bodies of the locus coeruleus and reducing the NE content of the hippocampus and substantia nigra by 45 and 69%. Rats were tested both 5 and 36 days after lesioning for their startle response to repetitive series of tactile stimuli. On both days, locus coeruleus lesioned rats exhibited consistently reduced startle responses throughout the stimulus series. Additionally, lesioned rats showed a far more rapid rate of response habituation, particularly in the 1st test. The possible influence of the locus coeruleus on the process of sensitization to sensory stimuli is discussed.