The African Descent and Glaucoma Evaluation Study (ADAGES): Predictors of Visual Field Damage in Glaucoma Suspects
The African Descent and Glaucoma Evaluation Study (ADAGES): Predictors of Visual Field Damage in Glaucoma Suspects
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DOI：
10.1016/j.ajo.2015.01.011
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发表时间：
2015-04-01
影响因子：
4.2
通讯作者：
Zangwill, Linda M.
中科院分区：
文献类型：
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作者：
Khachatryan, Naira;Medeiros, Felipe A.;Zangwill, Linda M.
目得：评估种族差异的发展视野（VF）损害的青光眼suspectors.DESIGN：前瞻性，观察性队列study.METHODS：六百三十六只眼睛从357青光眼嫌疑人正常VF在基线被列入多中心非洲裔和青光眼评估研究（ADAGES）。使用多变量考克斯比例风险模型检查了VF损伤发展的种族差异。结果：122名非洲裔参与者中有31名（25.4%）和235名欧洲裔参与者中有47名（20.0%）出现VF损伤（P = 0.078）。在多变量分析中，更差的基线VF平均偏差、随访期间更高的平均动脉压以及种族 * 平均眼内压（TOP）相互作用项与VF损伤的发生显著相关，表明VF损伤风险的种族差异因TOP而异。在较高的平均TOP水平，种族是预测VF损伤的发展，即使在调整潜在的混杂因素。在随访期间平均IOP为22、24和26 mm Hg时，非洲裔受试者与欧洲裔受试者相比发生VF损伤的多变量风险比（95%置信区间）分别为2.03（1.15-3.57）、2.71（1.39-5.29）和3.61（1.61-8.08）。然而，在较低的平均TOP水平（低于22毫米汞柱）在后续行动中，非洲裔是没有预测的VF damage.CONCLUSION的发展：在这个队列的青光眼嫌疑人具有类似的访问到治疗，多变量分析显示，在较高的平均TOP在后续行动中，非洲裔的个人更有可能发展VF损伤比欧洲裔的个人。(C)2015年，Elsevier Inc. All rights reserved.
PURPOSE: To evaluate racial differences in the development of visual field (VF) damage in glaucoma suspects.DESIGN: Prospective, observational cohort study.METHODS: Six hundred thirty-six eyes from 357 glaucoma suspects with normal VF at baseline were included from the multicenter African Descent and Glaucoma Evaluation Study (ADAGES). Racial differences in the development of VF damage were examined using multi-variable Cox proportional hazard models.RESULTS: Thirty one of 122 African-descent participants (25.4%) and 47 of 235 European-descent participants (20.0%) developed VF damage (P =.078). In multivariable analysis, worse baseline VF mean deviation, higher mean, arterial pressure during follow-up, and a race * mean intraocular pressure (TOP) interaction term were significantly associated with the development of VF damage, suggesting that racial differences in the risk of VF damage varied by TOP. At higher mean TOP levels, race was predictive of the development of VF damage even after adjusting for potentially confounding factors. At mean IOPs during follow-up of 22, 24, and 26 mm Hg, multivariable hazard ratios (95% confidence intervals) for the development of VF damage in African-descent compared to European-descent subjects were 2.03 (1.15-3.57), 2.71 (1.39-5.29), and 3.61 (1.61-8.08), respectively. However, at lower mean TOP levels (below 22 mm Hg) during follow-up, African descent was not predictive of the development of VF damage.CONCLUSION: In this cohort of glaucoma suspects with similar access to treatment, multivariate analysis revealed that at higher mean TOP during follow-up, individuals of African descent were more likely to develop VF damage than individuals of European descent. (C) 2015 by Elsevier Inc. All rights reserved.