Subtraction ICG angiography in Harada's disease
Subtraction ICG angiography in Harada's disease
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DOI：
10.1136/bjo.83.7.822
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发表时间：
1999-07-01
影响因子：
4.1
通讯作者：
De Laey, JJ
中科院分区：
文献类型：
--
作者：
Kohno, T;Miki, T;De Laey, JJ
背景/目的-吲哚菁绿色（ICG）血管造影（ICGA）在原田病中的意义在许多方面仍有待澄清。本研究探讨了详细的脉络膜病变观察原田病的减法methods-Eight患者原田病随后与ICGA。使用Topcon高分辨率数字眼底照相机获得ICG血管造影片，并使用Topcon IMAGEnet计算机系统进行处理。图像减影tvas进行分析，在约2秒的时间间隔，在染料运输阶段和那些采取的早期和中期阶段的血管造影。结果标准ICG图像的急性期疾病显示延迟脉络膜填充在早期阶段。中期血管造影显示不同强度的明亮荧光区域，表明脉络膜内ICG渗漏。通过以秒为间隔的血管造影片的图像减影，脉络膜血管可以依次成像，首先可视化脉络膜动脉，然后定义脉络膜毛细血管，然后是脉络膜静脉。延迟充盈的脉络膜静脉在连续减影血管造影中显示为阳性图像。间隔分钟的减影显示不均匀的背景荧光和与脉络膜内ICG渗漏区域对应的明亮荧光。类固醇治疗后，血管造影显示脉络膜延迟充盈改善。图像减影的第二个允许一个清晰的可视化的改善脉络膜静脉填充，而减影分钟显示均匀的背景荧光，消除较亮的areas.Conclusion-Subtraction ICGA表明，延迟填充的脉络膜静脉的不同严重程度发生在与高渗透性的脉络膜血管原田病的过程中。
Background/aim-The significance of indocyanine green (ICG) angiography (ICGA) in Harada's disease still awaits clarification in many respects. This study investigates the details of choroidal lesions observed in Harada's disease by the subtraction method.Methods-Eight patients with Harada's disease were followed with ICGA. ICG angiograms were obtained with a Topcon high resolution digital fundus camera and processed with a Topcon IMAGEnet computer system. Image subtraction tvas conducted for analysing serial angiograms taken at about 2 second intervals during the dye transit phase and those taken in the early and middle phases of angiography.Results-Standard ICG images of acute stage disease showed delayed choroidal filling in the early phase. Mid phase angiograms showed areas with bright fluorescence of variable intensity, indicating intrachoroidal ICG leakage. With image subtraction of angiograms with an interval of seconds the choroidal vessels could be imaged sequentially, with the choroidal arteries visualised first, followed by the definition of the choriocapillaris and then the choroidal veins. The choroidal veins with delayed filling were visualised as positive images in serial subtraction angiograms. Subtraction with an interval of minutes showed uneven background fluorescence and bright fluorescence corresponding to the areas of intrachoroidal ICG leakage. After the disease subsided with steroid therapy angiography revealed an improvement in delayed choroidal filling. Image subtraction by the second allowed a clear visualisation of improved choroidal venous filling, while subtraction by the minute showed homogeneous background fluorescence,eliminating brighter areas.Conclusion-Subtraction ICGA demonstrated that delayed filling of the choroidal veins of varying severity occurs in association with hyperpermeability of the choroidal vessels in the course of Harada's disease.