Pentraxin levels in non-eosinophilic versus eosinophilic asthma
Pentraxin levels in non-eosinophilic versus eosinophilic asthma
复制标题
非嗜酸性粒细胞性哮喘与嗜酸性粒细胞性哮喘中的五聚蛋白水平
DOI：
10.1111/cea.13168
复制
发表时间：
2018-08-01
影响因子：
6.1
通讯作者：
Xie, Jungang
中科院分区：
文献类型：
--
作者：
Gao, Pengfei;Tang, Kun;Xie, Jungang
背景天然免疫被认为参与了哮喘的发病机制。五聚素作为可溶性的模式识别分子，在体液天然免疫中起着重要作用。哮喘是一种异质性气道炎症性疾病，可分为嗜酸性粒细胞性或非嗜酸性粒细胞性Asthma. Objectivepentraxin水平是否与嗜酸性粒细胞性哮喘与非嗜酸性粒细胞性哮喘受试者不同。此外，要访问五聚环肽水平的预测性能区分哮喘炎症phenotypes.MethodsA共80例哮喘患者和24名健康对照组进行痰诱导在研究纳入。对选定痰液进行白细胞分类计数。采用酶联免疫吸附法测定血浆C反应蛋白（CRP）、血清淀粉样蛋白P（SAP）、正五聚蛋白3（PTX 3）和痰液SAP、PTX 3、IL-8水平。结果与嗜酸性粒细胞性哮喘和健康对照组相比，非嗜酸性粒细胞性哮喘受试者的正五聚蛋白水平显着升高，中位数血浆CRP水平分别为0.86（0.28-2.07）、0.26（0.14-0.85）和0.15（0.09-0.45）mg/L（四分位距）（P
BackgroundInnate immunity has been thought to be involved in asthma pathogenesis. Pentraxins, acting as soluble pattern recognition molecules, play an important role in humoral innate immunity. Asthma is a heterogeneous inflammatory disease of airways and can be classified as eosinophilic or non-eosinophilic asthma.ObjectiveTo investigate whether pentraxin levels differ in subjects with eosinophilic versus non-eosinophilic asthma. Furthermore, to access the predictive performance of pentraxin levels for discriminating asthma inflammatory phenotypes.MethodsA total of 80 asthmatic patients and 24 healthy control subjects underwent sputum induction at study inclusion. Differential leucocyte counts were performed on selected sputum. Plasma C-reactive protein (CRP), serum amyloid P (SAP), pentraxin 3 (PTX3), and sputum SAP, PTX3, IL-8 levels were determined by enzyme-linked immunosorbent assay.ResultsSubjects with non-eosinophilic asthma had significantly increased pentraxin levels compared with those with eosinophilic asthma and healthy controls, with median (interquartile range) plasma CRP levels of 0.86 (0.28-2.07), 0.26 (0.14-0.85), and 0.15 (0.09-0.45)mg/L (P