Targeting RNA with cysteine-constrained peptides
Targeting RNA with cysteine-constrained peptides
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DOI：
10.1016/j.bmcl.2007.11.096
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发表时间：
2008-01-15
影响因子：
2.7
通讯作者：
Melander, Christian
中科院分区：
文献类型：
--
作者：
Burns, Virginia A.;Bobay, Benjamin G.;Melander, Christian
已经使用环肽文库和计算机模拟开发了一种用于用新型生物活性配体靶向RNA的组合方法。这种方法已经成功地鉴定了可以靶向bTAR RNA的新型环肽构建体。随后，RNA/肽的相互作用，有效地建模使用HADDOCK对接程序。(c)2007爱思唯尔有限公司保留所有权利。
A combined approach for targeting RNA with novel, biologically active ligands has been developed using a cyclic peptide library and in silico modeling. This approach has successfully identified novel cyclic peptide constructs that can target bTAR RNA. Subsequently, RNA/peptide interactions were effectively modeled using the HADDOCK docking program. (c) 2007 Elsevier Ltd. All rights reserved.