Individualizing the use of medications in children: making Goldilocks happy.
Individualizing the use of medications in children: making Goldilocks happy.
复制标题
个体化儿童药物使用：让金发姑娘快乐。
DOI：
10.1038/clpt.2014.130
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发表时间：
2014
影响因子：
6.7
通讯作者：
Soden,SE
中科院分区：
文献类型：
--
作者：
Leeder,JS;Brown,JT;Soden,SE
到目前为止，儿童精准医疗的实施有限。成人经验的外推简化了儿科药物开发计划，基于生理的药代动力学模型有助于儿童在人群基础上选择剂量。为了实现临床可行的药物治疗个体化，基因型分层药代动力学研究可以有效地表征剂量-暴露关系的极端情况。通过基于基因型的给药来减少暴露的可变性，可以改善对导致反应的遗传因素的识别，最终改善儿童的药物治疗。临床药理学与治疗学（2014）；963年,304 - 306。提前在线出版2014年7月23日。doi: 10.1038 / clpt.2014.130
To date, implementation of precision medicine for children has been limited. Extrapolation of adult experience streamlines pediatric drug development programs, and physiologically based pharmacokinetic models aid pediatric dose selection on a population basis. To achieve clinically viable individualization of drug therapy, genotype‐stratified pharmacokinetic studies can efficiently characterize the extremes of the dose–exposure relationship. Reducing variability in exposure through genotype‐based dosing may improve identification of genetic factors contributing to response, ultimately improving drug therapy for children.Clinical Pharmacology & Therapeutics(2014);963, 304–306. advance online publication 23 July 2014. doi:10.1038/clpt.2014.130