The vaccination coverage required to establish herd immunity against influenza viruses
The vaccination coverage required to establish herd immunity against influenza viruses
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DOI：
10.1016/j.ypmed.2012.02.015
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发表时间：
2012-07-01
影响因子：
5.1
通讯作者：
Plans-Rubio, Pedro
中科院分区：
文献类型：
--
作者：
Plans-Rubio, Pedro
目标。1)确定建立群体免疫所需的流感疫苗接种覆盖率；2)评估建议接种覆盖率和美国和欧洲注册的接种覆盖率是否足以建立群体免疫。通过考虑每个感染病例的继发病例数(R-O)和疫苗效力来确定建立群体免疫所需的疫苗接种率。对于1918-1919、1957-58年、1968-69年和2009-10年大流行病毒，建立针对先前流感病毒的群体免疫力所需的百分比从13%到100%不等。而对于2008-09年的疫情病毒，从30%到40%。美国建议的疫苗接种覆盖率目标--80%在健康人中，90%在高危人群中--足以建立群体免疫，而欧洲仅建议的目标--75%在老年人和高危人群中--是不够的。美国和欧洲登记的疫苗接种率不足以建立群体免疫。必须提高美国和欧洲的流感疫苗接种覆盖率，才能建立群体免疫。有必要开发基于群体免疫的新的流感预防信息。(C)2012 Elsevier Inc.保留所有权利。
Objective. 1) To determine the influenza vaccination coverage required to establish herd immunity, and 2) to assess whether the percentages of vaccination coverage proposed and those registered in the United States and Europe are sufficient to establish herd immunity.Methods. The vaccination coverage required to establish herd immunity was determined by taking into account the number of secondary cases per infected case (R-o) and the vaccine effectiveness.Results. The required percentage that would have been required to establish herd immunity against previous influenza viruses ranged from 13% to 100% for the 1918-19, 1957-58, 1968-69 and 2009-10 pandemic viruses. and from 30% to 40% for the 2008-09 epidemic virus. The objectives of vaccination coverage proposed in the United States - 80% in healthy persons and 90% in high-risk persons are - sufficient to establish herd immunity, while those proposed in Europe only - 75% in elderly and high-risk persons are not sufficient. The percentages of vaccination coverage registered in the United States and Europe are not sufficient to establish herd immunity.Conclusion. The influenza vaccination coverage must be increased in the United States and Europe in order to establish herd immunity. It is necessary to develop new influenza prevention messages based on herd immunity. (C) 2012 Elsevier Inc. All rights reserved.