Frenemies: Signaling and Nutritional Integration in Pathogen-Microbiota-Host Interactions.
Frenemies: Signaling and Nutritional Integration in Pathogen-Microbiota-Host Interactions.
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DOI：
10.1016/j.chom.2015.08.007
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发表时间：
2015-09-09
影响因子：
30.3
通讯作者：
Sperandio V
中科院分区：
文献类型：
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作者：
Cameron EA;Sperandio V
哺乳动物胃肠道（GI）微生物群高度适应于在GI环境中茁壮成长，并执行与宿主营养、生理、发育、免疫和行为相关的关键功能。成功的宿主细菌协会需要化学信号和最佳的营养利用和交换。然而，这种重要的平衡可能会被环境刺激严重破坏，对微生物群最常见的伤害之一是传染病。虽然微生物群作为肠道病原体的屏障，但许多肠道病原体利用来自微生物群和宿主的信号和营养物来调节其毒力程序。在这里，我们回顾了几个信号和营养识别系统采用GI病原体调节生长和毒力。我们讨论了微生物群组成的变化如何改变宿主对感染的易感性，以及饮食变化或微生物群的操纵如何可能预防和/或改善GI感染。
The mammalian gastrointestinal (GI) microbiota is highly adapted to thrive in the GI environment and performs key functions related to host nutrition, physiology, development, immunity, and behavior. Successful host-bacterial associations require chemical signaling and optimal nutrient utilization and exchange. However, this important balance can be severely disrupted by environmental stimuli, with one of most common insults upon the microbiota being infectious diseases. Although the microbiota acts as a barrier towards enteric pathogens, many enteric pathogens exploit signals and nutrients derived from both the microbiota and host to regulate their virulence programs. Here we review several signaling and nutrient recognition systems employed by GI pathogens to regulate growth and virulence. We discuss how shifts in the microbiota composition change host susceptibility to infection, and how dietary changes or manipulation of the microbiota could potentially prevent and/or ameliorate GI infections.