Abnormal vocal behavior predicts executive and memory deficits in Alzheimer's disease.
Abnormal vocal behavior predicts executive and memory deficits in Alzheimer's disease.
复制标题
DOI：
10.1016/j.neurobiolaging.2016.12.020
复制
发表时间：
2017-04
影响因子：
4.2
通讯作者：
Houde JF
中科院分区：
文献类型：
--
作者：
Ranasinghe KG;Gill JS;Kothare H;Beagle AJ;Mizuiri D;Honma SM;Gorno-Tempini ML;Miller BL;Vossel KA;Nagarajan SS;Houde JF
说话者会自动且快速地做出反应，以补偿其听觉反馈中音调的短暂扰动。发声输出的特定调整需要整合参与言语运动控制的大脑区域，以便检测感觉反馈错误并实施运动校正。参与音调反射现象的皮质区域是阿尔茨海默病（AD）中网络破坏的高度易损靶点。我们将19名AD患者与16名年龄匹配的对照组进行了音调反射的检测。我们测量了行为补偿程度（峰值补偿）和适应性反应程度（音调反应持续性）。健康对照组的峰值补偿达到18.7±0.8音分，并在8.9±0.69音分处表现出持续补偿。相比之下，AD患者的峰值补偿显著升高（22.4±1.2音分，P<0.05），持续反应降低（音调反应持续性，4.5±0.88音分，P<0.001）。在AD患者中，峰值补偿增加的程度可预测执行功能障碍，而音调反应持续性受损的程度可预测记忆功能障碍。当前研究表明，音调反射是AD中感觉运动整合的前额叶调节受损以及记忆的可塑性机制受损的敏感行为指标。
Speakers respond automatically and rapidly to compensate for brief perturbations of pitch in their auditory feedback. The specific adjustments in vocal output require integration of brain regions involved in speech-motor-control in order to detect the sensory-feedback-error and implement the motor-correction. Cortical regions involved in the pitch-reflex phenomenon are highly vulnerable targets of network disruption in Alzheimer's disease (AD). We examined the pitch-reflex in AD patients (n=19) compared to an age-matched control group (n=16). We measured the degree of behavioral compensation (peak-compensation) and the extent of the adaptive response (pitch-response-persistence). Healthy-controls reached a peak-compensation of 18.7±0.8 cents, and demonstrated a sustained compensation at 8.9±0.69 cents. AD patients, in contrast, demonstrated a significantly elevated peak-compensation (22.4±1.2 cents, P<0.05), and a reduced sustained response (pitch-response-persistence, 4.5±0.88 cents, P<0.001). The degree of increased peak-compensation predicted executive dysfunction, while the degree of impaired pitch-response-persistence predicted memory dysfunction, in AD patients. The current study demonstrates pitch-reflex as a sensitive behavioral index of impaired prefrontal modulation of sensorimotor integration, and compromised plasticity mechanisms of memory, in AD.