Effects of deafness and cochlear implant use on temporal response characteristics in cat primary auditory cortex
Effects of deafness and cochlear implant use on temporal response characteristics in cat primary auditory cortex
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DOI：
10.1016/j.heares.2014.06.001
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发表时间：
2014-09-01
期刊：
影响因子：
2.8
通讯作者：
Irvine, Dexter R. F.
中科院分区：
文献类型：
--
作者：
Fallon, James B.;Shepherd, Robert K.;Irvine, Dexter R. F.
我们以前已经证明，持续7-13个月的新生儿耳聋会导致初级听觉皮质(Al)的耳蜗性耳聋，这种情况可以通过人工耳蜗术来逆转。在这里，我们描述了类似的耳聋持续时间和人工耳蜗使用对时间加工的影响。具体地说，我们比较了年轻的成年正常听力猫在记录前立即被急性耳聋和植入的A1神经元的时间分辨率与三组新生儿耳聋猫的时间分辨率。其中一组新生儿耳聋的猫没有接受慢性刺激。另外两组从10周大的临床人工耳蜗开始，接受长达8个月的低或高频率(每个电极分别为每秒50或500脉冲)刺激。持续7-13个月的耳聋对发病后反应抑制的持续时间、潜伏期、潜伏期抖动或单位最大反应的刺激重复率(最佳重复率)没有影响，但导致单位对列车中每个刺激的反应能力(最大追随率)在统计学上显著降低。低频率组的时间反应特征与急性耳聋对照组没有不同之处。相比之下，高频率刺激有不同的效果：与所有其他组相比，它导致抑制持续时间缩短，潜伏期延长，抖动增加，最佳重复率和截断率相对于剧烈耳聋的对照组增加。在本研究中，中度耳聋对时间加工的影响是最小的，与先前报道的对耳蜗术的显著影响形成对比。据报道，更长的耳聋时间会导致时间加工的显著变化，这与耳聋持续时间是影响人工耳蜗植入者预后的主要因素相一致。(C)2014爱思唯尔B.V.保留所有权利。
We have previously shown that neonatal deafness of 7-13 months duration leads to loss of cochleotopy in the primary auditory cortex (Al) that can be reversed by cochlear implant use. Here we describe the effects of a similar duration of deafness and cochlear implant use on temporal processing. Specifically, we compared the temporal resolution of neurons in Al of young adult normal-hearing cats that were acutely deafened and implanted immediately prior to recording with that in three groups of neonatally deafened cats. One group of neonatally deafened cats received no chronic stimulation. The other two groups received up to 8 months of either low-or high-rate (50 or 500 pulses per second per electrode, respectively) stimulation from a clinical cochlear implant, initiated at 10 weeks of age. Deafness of 7-13 months duration had no effect on the duration of post-onset response suppression, latency, latency jitter, or the stimulus repetition rate at which units responded maximally (best repetition rate), but resulted in a statistically significant reduction in the ability of units to respond to every stimulus in a train (maximum following rate). None of the temporal response characteristics of the low-rate group differed from those in acutely deafened controls. In contrast, high-rate stimulation had diverse effects: it resulted in decreased suppression duration, longer latency and greater jitter relative to all other groups, and an increase in best repetition rate and cut-off rate relative to acutely deafened controls. The minimal effects of moderate-duration deafness on temporal processing in the present study are in contrast to its previously-reported pronounced effects on cochleotopy. Much longer periods of deafness have been reported to result in significant changes in temporal processing, in accord with the fact that duration of deafness is a major factor influencing outcome in human cochlear implantees. (C) 2014 Elsevier B.V. All rights reserved.