Mechanisms of Invasion and Metastasis
Mechanisms of Invasion and Metastasis
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侵袭和转移机制
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
F. Roy
中科院分区：
文献类型：
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作者：
M. Mareel;P. Baetselier;F. Roy
介绍。侵袭和转移的临床方面。MALIGNANCY-RELATED表型。用于分析的模型。表型标准。表型组合。表型之间的转换：肿瘤发展的领域和进展理论。转移的模式。解剖方面的考虑。晚期转移。转移或第二原发。影响侵袭和转移的因素。肿瘤-宿主生态系统相关因素。环境因素。疗法。侵袭和转移：肿瘤恶性的决定因素。总结。侵袭和转移的生物测定。一般注意事项。侵袭和转移的体外生物测定。机关文化。组织外植体。重组组织。细胞培养。矩阵。组织提取。体内侵袭试验。皮下接种。腹腔内注射。在特定部位接种。注射到血管系统。体内转移试验。M型之间的歧视。Mspo和Mexp测定的当前模型。M型的得分。检测的相关性。总结和结论。与侵袭和转移有关的细胞活动。细胞-细胞附着是恶性肿瘤的一个因素。细胞-细胞粘附分子的结构与发生。细胞-细胞粘附分子的正常作用。细胞粘附分子在恶性肿瘤中的作用。细胞间连接通讯在恶性肿瘤中的作用。细胞-底物相互作用作为恶性肿瘤的因素。细胞外基质（ECM）：一个涉及恶性肿瘤的多功能网络。整合素：ECM成分的主要受体。胶原蛋白和弹性蛋白：ECM骨架和支架。纤维连接蛋白、其他整合素配体及其受体。Tenascin / Cytotactin。层粘连蛋白。糖胺聚糖和蛋白聚糖。水解酶活性作为恶性肿瘤的因素。水解酶是否与侵袭和转移有关？肿瘤相关水解酶综述。丝氨酸蛋白酶与恶性肿瘤。组织蛋白酶与恶性肿瘤。异基因蛋白酶与恶性肿瘤。糖苷酶与恶性肿瘤。水解酶和水解酶级联之间的协同作用。与恶性肿瘤相关的水解酶的其他活性。运动和迁移是恶性肿瘤的因素。流动和迁移的概念。运动是否与侵袭和转移有关？运动调节因子可能与恶性肿瘤有关。评估和总结。宿主对侵袭和转移的贡献。原发部位的宿主-肿瘤相互作用。肿瘤相关白细胞：起源和积聚的调控。肿瘤相关白细胞：肿瘤发展过程中的积累和激活。肿瘤-宿主成分作为恶性肿瘤的组成部分。循环中宿主与肿瘤的相互作用。宿主成分在肿瘤细胞阻滞和寄存中的作用。宿主成分在肿瘤细胞外渗中的作用。宿主-肿瘤在次要部位的相互作用。宿主介导的Im表型控制。宿主介导的转基因表型控制。Tum或cell获取
INTRODUCTION. CLINICAL ASPECTS OF INVASION AND METASTASIS. MALIGNANCY-RELATED PHENOTYPES. A Model for Analysis. Criteria for Phenotyping. Combinations of Phenotypes. TRANSITIONS BETWEEN PHENOTYPES: FIELD AND PROGRESSION THEORIES OF TUMOR DEVELOPMENT. PATTERNS OF METASTASIS. Anatomical Considerations. Late Metastases. Metastasis or Second Primary. FACTORS INFLUENCING INVASION AND METASTASIS. Factors Related to the Tumor-Host Ecosystem. Environmental Factors. Therapeutics. INVASION AND METASTASIS: DETERMINANTS OF TUMOR MALIGNANCY. SUMMARY. BIOASSAYS FOR INVASION AND METASTASIS. GENERAL CONSIDERATIONS. IN VITRO BIOASSAYS FOR INVASION AND METASTASIS. Organ Culture. Tissue Explants. Reconstituted Tissues. Cell Cultures. Matrices. Tissue Extracts. IN VIVO ASSAYS FOR INVASION. Subcutaneous Inoculation. Intraperitoneal Injections. Inoculations at Particular Sites. Injections into the Vasculature. IN VIVO ASSAYS FOR METASTASIS. Discrimination Between M Phenotypes. Current Models for Mspo and Mexp Assays. Scores for the M Phenotype. Relevance of the Assays. SUMMARY AND CONCLUSIONS. CELLULAR ACTIVITIES IMPLICATED IN INVASION AND METASTASIS. CELL-CELL ATTACHMENT AS AN ELEMENT OF MALIGNANCY. Structure and Occurrence of Cell-Cell Adhesion Molecules. Normal Role of Cell-Cell Adhesion Molecules. Role of Cell-Cell Adhesion Molecules in Malignancy. Role of Intercellular Junctional Communication in Malignancy. CELL-SUBSTRATE INTERACTIONS AS ELEMENTS OF MALIGNANCY. Extracellular Matrix (ECM): A Multifunctional Network Implicated in Malignancy. Integrins: Major Receptors for ECM Components. Collagens and Elastin: ECM Skeletons and Scaffolds. Fibronectin, Some Other Integrin Ligands, and Their Receptors. Tenascin/Cytotactin. Laminin. Glycosaminoglycans and Proteoglycans. HYDROLASE ACTIVITIES AS ELEMENTS OF MALIGNANCY. Are Hydrolases Implicated in Invasion and Metastasis? Overview of Tumor-Associated Hydrolases. Serine Proteases and Malignancy. Cathepsins and Malignancy. Met alloproteases and Malignancy. Glycosidases and Malignancy. Synergism Between Hydrolases and Hydrolases Cascades. Additional Activities of Hydrolases Implicated in Malignancy. MOTILITY AND MIGRATION AS ELEMENTS OF MALIGNANCY. Notions of Motility and Migration. Is Motility Implicated in Invasion and Metastasis? Motility-Modulating Factors Possibly Implicated in Malignancy. EVALUATION AND SUMMARY. CONTRIBUTIONS OF THE HOST TO INVASION AND METASTASIS. HOST-TUMOR INTERACTIONS AT THE PRIMARY SITE. Tumor-Associated Leukocytes: Origin and Regulation of Accumulation. Tumor-Associated Leukocytes: Accumulation and Activation During Neoplastic Development. Tumor-Host Components as Elements of Malignancy. HOST-TUMOR INTERACTIONS IN THE CIRCULATION. Role of Host Components in Tumor Cell Arrest and Lodgement. Role of Host Components in Tumor Cell Extravasation. HOST-TUMOR INTERACTIONS AT SECONDARY SITES. Host-Mediated Control of the Im Phenotype. Host-Mediated Control of the Gm Phenotype. TUM OR CELL ACQUISITION