THROMBOCYTOSIS ASSOCIATED WITH MALIGNANT DISEASE
THROMBOCYTOSIS ASSOCIATED WITH MALIGNANT DISEASE
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DOI：
10.1001/archinte.1964.03860100079008
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发表时间：
1964-01-01
影响因子：
--
通讯作者：
CONLEY, CL
中科院分区：
文献类型：
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作者：
LEVIN, J;CONLEY, CL
血小板与血栓形成密切相关。我们的资料表明，血小板增多症通常与肿瘤有关，有时程度显著。因此，肿瘤患者循环血小板的增加可能与他们发生血栓性静脉炎的倾向有关。血小板增多的机制尚不清楚，但肿瘤直接累及骨髓似乎并不必要。血小板增多症通常被认为是骨髓增生性疾病的指标。它可以提供一个线索，以前未怀疑的疾病，并可能是特别有价值的潜在恶性疾病的患者的诊断是不确定的指标。
Platelets are importantly concerned with thrombus formation. Our data indicate that thrombocytosis is commonly associated with neoplasms and is sometimes of marked degree. It seems possible, therefore, that the increase of circulating platelets in patients with tumors may be related to their tendency to develop thrombophlebitis. The mechanism by which the thrombocytosis is produced is unknown; however, direct involvement of the bone marrow by the tumor does not appear to be necessary. Thrombocytosis is often considered to be an indicator of a myeloproliferative disease. It may provide a clue to previously unsuspected disease and may be especially valuable as an indicator of underlying malignant disease in patients in whom the diagnosis is uncertain.