Environmental Isolation of Candida auris from the Coastal Wetlands of Andaman Islands, India.
Environmental Isolation of Candida auris from the Coastal Wetlands of Andaman Islands, India.
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DOI：
10.1128/mbio.03181-20
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发表时间：
2021-03-16
期刊：
影响因子：
6.4
通讯作者：
Chowdhary A
中科院分区：
文献类型：
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作者：
Arora P;Singh P;Wang Y;Yadav A;Pawar K;Singh A;Padmavati G;Xu J;Chowdhary A
耳念珠菌是近年来发现的一种耐多药真菌病原体，可引起住院患者严重感染。尽管早在10年前就被认为是人类病原体，但迄今为止，C。奥里斯仍然是个谜。耳念珠菌是一种多重耐药病原体，对人类健康构成严重的全球威胁。作为C.耳道炎是一种新出现的病原体，其生态位的一些问题尚未得到解决。与C.虽然在不同的环境生境中发现了耳道线虫，但对耳道线虫的自然生境知之甚少。耳。在这里，我们探索了印度洋中与世隔绝的安达曼群岛周围的原始栖息地，以寻找C。耳。我们采样沿海湿地，包括岩石海岸，桑迪，潮汐沼泽，和红树林沼泽，周围的安达曼和尼科巴群岛，联合领土，在印度。从8个采样点采集了48个沉积物、土壤和海水样品，这些样品代表了南安达曼地区东西海岸潮间带生境的异质性。C.在八个采样点中的两个，即一个盐沼和一个桑迪海滩，发现了耳虱。有趣的是，多药敏感和多药耐药的C。样本中发现耳道分离株。全基因组测序分析将C. auris分离物分为进化枝I，显示出与来自南亚的其他分离物的密切相似性。分离C.来自热带沿海环境的耳音表明它与海洋生态系统有关。可行的C. auris在海洋环境中的检测结果证实了C.在恶劣的湿地生存。然而，C.盐沼湿地和桑迪中的耳道线虫对人类的感染情况有待进一步探讨。
Candida auris is a recently emerged multidrug-resistant fungal pathogen capable of causing severe infections in hospitalized patients. Despite its recognition as a human pathogen a decade ago, so far the natural ecological niche(s) of C. auris remains enigmatic. Candida auris is a multidrug resistant pathogen that presents a serious global threat to human health. As C. auris is a newly emerged pathogen, several questions regarding its ecological niche remain unexplored. While species closely related to C. auris have been detected in different environmental habitats, little is known about the natural habitat(s) of C. auris. Here, we explored the virgin habitats around the very isolated Andaman Islands in the Indian Ocean for evidence of C. auris. We sampled coastal wetlands, including rocky shores, sandy beaches, tidal marshes, and mangrove swamps, around the Andaman group of the Andaman & Nicobar Islands, Union Territory, in India. Forty-eight samples of sediment soil and seawater were collected from eight sampling sites representing the heterogeneity of intertidal habitats across the east and west coast of South Andaman district. C. auris was isolated from two of the eight sampling sites, a salt marsh and a sandy beach. Interestingly, both multidrug-susceptible and multidrug-resistant C. auris isolates were found in the sample. Whole-genome sequencing analysis clustered the C. auris isolates into clade I, showing close similarity to other isolates from South Asia. Isolation of C. auris from the tropical coastal environment suggests its association with the marine ecosystem. The fact that viable C. auris was detected in the marine habitat confirms C. auris survival in harsh wetlands. However, the ecological significance of C. auris in salt marsh wetland and sandy beaches to human infections remains to be explored.