Promotion by unsaturated fat of azaserine-induced pancreatic carcinogenesis in the rat.
Promotion by unsaturated fat of azaserine-induced pancreatic carcinogenesis in the rat.
复制标题
不饱和脂肪促进重氮丝氨酸诱导的大鼠胰腺癌发生。
作者：
B. Roebuck;James D. Yager;Daniel S. Longnecker;S. Wilpone
饮食已被证明可以调节动物中各种化学诱导癌症的发病率。各种饮食喂养期间的起始阶段或启动后（促进）阶段的致癌性进行了评估，他们的能力，以调节胰腺癌的发病率。雄性Wistar/刘易斯大鼠在6- 7周的起始阶段多次注射胰腺致癌物阿扎胞苷，并在34或44周的起始后阶段进行尸检。评价了以下饮食对胰腺肿瘤发生率的影响：高饱和脂肪;两种高不饱和脂肪（玉米油和红花油）;低蛋白;限制热量。在不饲喂试验饲料的阶段，饲喂纯化的对照饲料。通过光学显微镜评估胰腺腺瘤和腺癌的发生率。在初始阶段喂食热量限制饮食抑制胰腺肿瘤的发生率。在初始阶段，测试的其他饮食对胰腺癌的发病率没有影响。在启动后阶段，高不饱和脂肪饮食，但不是高饱和脂肪饮食显着升高胰腺肿瘤的发病率。低蛋白和热量限制饮食没有影响肿瘤发病率时，喂养在postinitiation阶段。因此，高不饱和脂肪的饮食似乎促进了阿扎色林治疗大鼠的胰腺癌发生，而高饱和脂肪的饮食未能显示出类似程度的胰腺癌发生的增强。
Diet has been shown to modulate the incidence of a wide variety of chemically induced cancers in animals. Various diets fed either during the initiation stage or the postinitiation (promotion) stage of carcinogenesis were evaluated for their ability to modulate the incidence of pancreatic cancer. Male Wistar/Lewis rats were treated with multiple injections of the pancreatic carcinogen, azaserine, during a 6- to 7-week-long initiation phase and were autopsied after a postinitiation phase of 34 or 44 weeks. The following diets were evaluated for their effects on the incidence of pancreatic neoplasms during each stage of carcinogenesis: high saturated fat; two high unsaturated fats (corn oil and safflower oil); low protein; and caloric restricted. A purified control diet was fed during that stage when the test diets were not fed. The incidence of pancreatic adenomas and adenocarcinomas was evaluated by light microscopy. Feeding of the caloric-restricted diet during the initiation phase suppressed the pancreatic neoplasm incidence. None of the ther diets tested had an effect on the incidence of pancreatic cancer during the initiation phase. During the postinitiation phase, both high-unsaturated-fat diets but not the high-saturated-fat diet significantly elevated the pancreatic neoplasm incidence. The low-protein and caloric-restricted diets had no effect on the neoplasm incidence when fed during the postinitiation phase. Thus, diets high in unsaturated fat appear to promote pancreatic carcinogenesis in the azaserine-treated rat while a diet high in saturated fat failed to show a similar degree of enhancement of pancreatic carcinogenesis.