The effect of mycophenolate mofetil on disease development in the gld.apoE (-/-) mouse model of accelerated atherosclerosis and systemic lupus erythematosus.
The effect of mycophenolate mofetil on disease development in the gld.apoE (-/-) mouse model of accelerated atherosclerosis and systemic lupus erythematosus.
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DOI：
10.1371/journal.pone.0061042
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Aprahamian T
中科院分区：
文献类型：
--
作者：
Richez C;Richards RJ;Duffau P;Weitzner Z;Andry CD;Rifkin IR;Aprahamian T
系统性红斑狼疮（SLE）是一种以自身抗体产生和累及多器官的炎症性疾病为特征的系统性自身免疫性疾病。早发动脉粥样硬化是SLE的常见并发症，可导致心血管疾病（CVD）的大量发病和死亡。SLE早期动脉粥样硬化的原因尚不完全清楚，尽管慢性炎症被认为起着重要作用。目前还没有已知的预防性治疗SLE过早动脉粥样硬化。霉酚酸酯（MMF）是一种免疫抑制剂，常用于治疗SLE患者。为了研究这种药物对小鼠狼疮疾病（包括过早的动脉粥样硬化发展）的影响，我们用MMF处理了gld.apoE−/−小鼠（SLE和加速动脉粥样硬化的模型）。我们让7周龄的gld.apoE−/−小鼠接受高胆固醇的西方饮食（含或不含MMF）。饮食12周后，与对照组相比，接受MMF的小鼠显示动脉粥样硬化病变面积减少。MMF治疗还改善了狼疮表型，表现为循环自身抗体水平显著降低，并改善了与该模型相关的狼疮肾炎。这些数据表明，霉酚酸酯对免疫系统的影响可能不仅对狼疮有益，而且对炎症驱动狼疮相关动脉粥样硬化也有益。
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is characterized by autoantibody production and inflammatory disease involving multiple organs. Premature atherosclerosis is a common complication of SLE and results in substantial morbidity and mortality from cardiovascular disease (CVD). The reasons for the premature atherosclerosis in SLE are incompletely understood, although chronic inflammation is thought to play an important role. There is currently no known preventative treatment of premature atherosclerosis in SLE. Mycophenolate mofetil (MMF) is an immunosuppressive agent that is commonly used for treatment of patients with SLE. In order to study the impact of this drug on murine lupus disease including premature atherosclerosis development, we treated gld.apoE−/− mice, a model of SLE and accelerated atherosclerosis, with MMF. We maintained seven-week old gld.apoE−/− mice on a high cholesterol Western diet with or without MMF. After 12 weeks on diet, mice receiving MMF showed decreased atherosclerotic lesion area compared to the control group. MMF treatment also improved the lupus phenotype, indicated by a significant decrease circulating autoantibody levels and ameliorating lupus nephritis associated with this model. This data suggests that the effects of MMF on the immune system may not only be beneficial for lupus, but also for inflammation driving lupus-associated atherosclerosis.
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影响因子：
158.5
作者：
Chan, TM;Li, FK;Lai, KN
通讯作者：
Lai, KN
影响因子：
13.6
作者：
Appel, Gerald B.;Contreras, Gabriel;Wofsy, David
通讯作者：
Wofsy, David
影响因子：
--
作者：
Jung, Hyejung;Bobba, Raja;Fortin, Paul R.
通讯作者：
Fortin, Paul R.
DOI：
10.1196/annals.1423.023
发表时间：
2007-01-01
期刊：
AUTOIMMUNITY, PT B: NOVEL APPLICATIONS OF BASIC RESEARCH
影响因子：
--
作者：
Gibson, William Thomas;Hayden, Michael Reuben
通讯作者：
Hayden, Michael Reuben
影响因子：
2.5
作者：
Ong, LM;Hooi, LS;Morad, Z
通讯作者：
Morad, Z