Prostate-specific Antigen (PSA) Testing Is Prevalent and Increasing in Stockholm County, Sweden, Despite No Recommendations for PSA Screening: Results from a Population-based Study, 2003-2011
Prostate-specific Antigen (PSA) Testing Is Prevalent and Increasing in Stockholm County, Sweden, Despite No Recommendations for PSA Screening: Results from a Population-based Study, 2003-2011
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DOI：
10.1016/j.eururo.2012.10.001
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发表时间：
2013-03-01
期刊：
影响因子：
23.4
通讯作者：
Gronberg, Henrik
中科院分区：
文献类型：
--
作者：
Nordstrom, Tobias;Aly, Markus;Gronberg, Henrik
背景：前列腺特异性抗原（PSA）检测在一些国家有所增加。对 PSA 检测模式的了解并不完整。目的：确定瑞典斯德哥尔摩县 PSA 检测的流行情况并探索 PSA 重新检测的模式。设计、设置和参与者：进行了一项基于人群的研究。通过注册链接，我们收集了人群信息、PSA 检测数据、病理报告和临床信息。研究人群包括 2011 年居住在斯德哥尔摩县的男性（n = 1 034 129），其中 229 872 人在 2003-2011 年期间进行了 PSA 测试。结果测量和统计分析：我们确定了 PSA 测试的有限持续时间点流行率，并对 40-89 岁男性的 PSA 重新测试进行了生存分析。结果和局限性：PSA 测试数量增加从 2003 年的 54 239 人增加到 2011 年的 124 613 人。在为期 9 年的研究期间，之前没有前列腺癌 (PCa) 诊断且年龄在 50-59 岁、60-69 岁和 70-79 岁的男性中分别有 46%、68% 和 77% 进行了 PSA 检测。 2010 年和 2011 年期间，50-59 岁、60-69 岁和 70-79 岁男性中分别有 25%、40% 和 46% 进行了 PSA 测试。 PSA 检测的普及率从 2003 年到 2011 年有所增加。重新检测的概率取决于 PSA 和年龄，如果第一个 PSA 值是 26 个月的累积发生率为 0.337（95% 置信区间，0.333-0.341）
Background: Prostate-specific antigen (PSA) testing has increased in several countries. There is incomplete knowledge of PSA testing patterns.Objective: Determine the prevalence of PSA testing and explore patterns of PSA retesting in Stockholm County, Sweden.Design, setting, and participants: A population-based study was performed. Through registry linkages, we collected population information, data on PSA tests, pathology reports, and clinical information. The study population comprised males living in Stockholm County in 2011 (n = 1 034 129), of which 229 872 had a PSA test during the period 2003-2011.Outcome measurements and statistical analysis: We determined limited-duration-point prevalence of PSA testing and performed survival analysis on PSA retesting for men aged 40-89 yr.Results and limitations: The number of PSA tests increased from 54 239 in 2003 to 124 613 in 2011. During the 9-yr study period, 46%, 68%, and 77% of men without a prior prostate cancer (PCa) diagnosis and aged 50-59 yr, 60-69 yr, and 70-79 yr, respectively, had a PSA test. During 2010 and 2011, 25%, 40%, and 46% of men aged 50-59 yr, 60-69 yr, and 70-79 yr, respectively, had a PSA test. The prevalence of PSA testing increased from 2003 to 2011. The probability of retesting was PSA and age dependent, with a 26-mo cumulative incidence of 0.337 (95% confidence interval, 0.333-0.341) if the first PSA value was