Binge-like acquisition of α-pyrrolidinopentiophenone (α-PVP) self-administration in female rats.
Binge-like acquisition of α-pyrrolidinopentiophenone (α-PVP) self-administration in female rats.
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DOI：
10.1007/s00213-018-4943-3
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发表时间：
2018-08
影响因子：
3.4
通讯作者：
Taffe MA
中科院分区：
文献类型：
--
作者：
Javadi-Paydar M;Harvey EL;Grant Y;Vandewater SA;Creehan KM;Nguyen JD;Dickerson TJ;Taffe MA
人工合成的卡西酮α-吡咯烷基苯丙酮（α-PVP）与使用者的奇怪公共行为有关。这种行为与药物使用的长期狂欢的关联激发了额外的研究，特别是因为先前的研究发现，一半的雄性大鼠经历了异常高摄入量的狂欢，随后在获得相关药物3，4-亚甲基二氧基吡咯戊酮的静脉内自我给药（IVSA）期间持续较低水平的自我给药。大鼠IVSA的暴食样获得模式是新的，因此本研究试图确定这种效应是否适用于雌性大鼠中α-PVP的IVSA。雌性Wistar大鼠在含有活动轮的实验室中接受α-PVP（0.05 mg/kg/inf）的IVSA训练。各组在轮子固定的情况下进行训练（无轮子组），在采集的最初5天固定或在整个采集过程中自由移动（轮子组）。然后对各组进行轮接入开关，然后对所有动物进行剂量替代（0.0125-0.3 mg/kg/inf），轮交替固定和自由移动。大约一半的大鼠开始他们的IVSA模式与一个狂欢日异常高水平的药物摄入量，独立的车轮访问条件。在采集后的车轮切换中，无车轮组的车轮活动要低得多。剂量效应曲线是相似的车轮访问培训组，狂欢/无狂欢表型亚组，并没有改变与车轮访问在剂量替代。这证实了α-PVP在雌性大鼠中的高促性腺激素有效性以及作为自然奖励的轮活动的伴随贬值。
The synthetic cathinone α-pyrrolidinopentiophenone (α-PVP) has been associated with bizarre public behavior in users. Association of such behavior with extended binges of drug use motivates additional investigation, particularly since a prior study found that half of male rats experience a binge of exceptionally high intake, followed by sustained lower levels of self-administration during the acquisition of intravenous self-administration (IVSA) of a related drug, 3,4-methylenedioxypyrovalerone. The binge-like acquisition pattern is novel for rat IVSA, thus the present study sought to determine if this effect generalizes to IVSA of α-PVP in female rats. Female Wistar rats were trained in IVSA of α-PVP (0.05 mg/kg/inf) in experimental chambers containing an activity wheel. Groups were trained with the wheels fixed (No-Wheel group), fixed for the initial 5 days of acquisition or free to move throughout acquisition (Wheel group). The groups were next subjected to a wheel-access switch and then all animals to dose-substitution (0.0125–0.3 mg/kg/inf) with the wheels alternately fixed and free to move. Approximately half of the rats initiated their IVSA pattern with a binge day of exceptionally high levels of drug intake, independent of wheel access condition. Wheel activity was much lower in the No-Wheel group in the wheel switch post-acquisition. Dose-effect curves were similar for wheel-access training groups, for binge/no binge phenotypic subgroups and were not altered with wheel access during the dose-substitution. This confirms the high reinforcer effectiveness of α-PVP in female rats and the accompanying devaluation of wheel activity as a naturalistic reward.
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影响因子：
4.7
作者：
Anneken JH;Angoa-Pérez M;Kuhn DM
通讯作者：
Kuhn DM
影响因子：
6.2
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1124/jpet.116.239376
发表时间：
2017-04-01
影响因子：
3.5
作者：
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通讯作者：
Collins, Gregory T.
影响因子：
4.7
作者：
Javadi-Paydar, Mehrak;Nguyen, Jacques D.;Taffe, Michael A.
通讯作者：
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