Metformin Use Is Associated With Reduced Mortality in a Diverse Population With COVID-19 and Diabetes.
Metformin Use Is Associated With Reduced Mortality in a Diverse Population With COVID-19 and Diabetes.
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DOI：
10.1101/2020.07.29.20164020
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发表时间：
2020-01-01
影响因子：
5.2
通讯作者：
Shalev, Anath
中科院分区：
文献类型：
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作者：
Crouse, Andrew B;Grimes, Tiffany;Shalev, Anath
背景技术背景：2019冠状病毒病（COVID-19）是一种日益严重的大流行病，死亡人数不断增加，与各种合并症以及种族差异有关。然而，这些高危人群的具体特征仍不清楚，缺乏降低死亡率的方法。方法：我们对2020年2月25日至6月22日期间在亚拉巴马大学伯明翰医院接受COVID-19检测的25，326名受试者进行了回顾性电子健康记录数据分析，美国南部种族多样性的三级医疗保健中心。主要结局是COVID-19阳性受试者的死亡率，并使用简单和多元线性logistic回归分析与受试者特征和合并症的相关性。结果：黑人/非洲裔美国人感染COVID-19的比值比不成比例地高（OR 2.6; 95%CI 2.19-3.10; p
BACKGROUND: Coronavirus disease-2019 (COVID-19) is a growing pandemic with an increasing death toll that has been linked to various comorbidities as well as racial disparity. However, the specific characteristics of these at-risk populations are still not known and approaches to lower mortality are lacking.METHODS: We conducted a retrospective electronic health record data analysis of 25,326 subjects tested for COVID-19 between 2/25/20 and 6/22/20 at the University of Alabama at Birmingham Hospital, a tertiary health care center in the racially diverse Southern U.S. The primary outcome was mortality in COVID-19-positive subjects and the association with subject characteristics and comorbidities was analyzed using simple and multiple linear logistic regression.RESULTS: The odds ratio of contracting COVID-19 was disproportionately high in Blacks/African-Americans (OR 2.6; 95%CI 2.19-3.10; p