Cardiovascular effects of growth hormone treatment: Potential risks and benefits
Cardiovascular effects of growth hormone treatment: Potential risks and benefits
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DOI：
10.1159/000080498
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Colao, A
中科院分区：
文献类型：
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作者：
Colao, A
生长激素（GH）和胰岛素样生长因子-I参与心脏发育和维持心脏结构和性能。据报道，心血管疾病会降低GH缺乏（GHD）和GH过量的预期寿命。患有GHD的患者患有左心室性能异常，即舒张期充盈减少和对峰值运动的反应受损。GHD患者的颈总动脉内膜中层厚度也增加，与动脉粥样硬化斑块的发生率较高相关，这可能进一步加重血液动力学状况。这可能会导致心血管和脑血管风险增加。这些心血管异常可以逆转，至少部分，与GH替代治疗。近年来，生长激素治疗已被用于增加缺血性或扩张型心肌病的心脏质量，但结果产生了矛盾的数据。版权所有（C）2004 S. Karger AG，巴塞尔。
Growth hormone (GH) and insulin-like growth factor-I are involved in heart development and in maintaining cardiac structure and performance. Cardiovascular disease has been reported to reduce life expectancy both in GH deficiency (GHD) and in GH excess. Patients with GHD suffer from abnormalities of left ventricular performance, i.e. reduced diastolic filling and impaired response to peak exercise. Patients with GHD also have increased intima-media thickness at the common carotid arteries, associated with a higher occurrence of atherosclerotic plaques, which may further aggravate the haemodynamic conditions. This may contribute to increased cardiovascular and cerebrovascular risk. These cardiovascular abnormalities can be reversed, at least partially, with GH replacement therapy. In recent years, GH therapy has been used to increase cardiac mass in ischaemic or dilated cardiomyopathy, but the results have produced contradictory data. Copyright (C) 2004 S. Karger AG, Basel.