FKBP5, SERT and COMT mRNA expressions in the peripheral leukocytes during menstruation cycle in healthy reproductive females
FKBP5, SERT and COMT mRNA expressions in the peripheral leukocytes during menstruation cycle in healthy reproductive females
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DOI：
10.1016/j.neulet.2008.01.039
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发表时间：
2008-03-21
影响因子：
2.5
通讯作者：
Ohmori, Tetsuro
中科院分区：
文献类型：
--
作者：
Kinouchi, Sawako;Iga, Jun-Ichi;Ohmori, Tetsuro
有证据表明，外周血白细胞中的mRNA表达不仅可以指示生理状态，还可以指示心理状态。本研究旨在探讨生殖健康女性月经周期白细胞mRNA表达的变化是否与心理状态有关。38名女性受试者（22.4 ± 11.4岁）在三个月经周期（月经期、卵泡期和黄体期）参与本研究。用激素数据测定白细胞中FKBP 5（FK 506结合蛋白基因）、SERT（5-羟色胺转运体基因）和COMT（儿茶酚-O-甲基转移酶基因）mRNA的表达。采用医院焦虑抑郁自评量表（HADS）评定患者的心理变化。只有三分之一的受试者（n = 12）在实验期间月经周期正常。所以我们分析了这12个受试者的数据。各受试者的焦虑评分随月经周期的变化而变化（Friedman检验：P < 0.05）。卵泡期FKBP 5 mRNA的表达显著低于其他各期，但SERT和COMT mRNA的表达在各期间无明显变化。总之，HADS焦虑评分和白细胞FKBP 5 mRNA表达在月经周期中存在差异，但焦虑评分与FKBP 5 mRNA之间无相关性。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
There have been several evidences that the mRNA expressions in the peripheral leukocytes may indicate not only physical but also psychological states. The purpose of this study is whether the mRNA expressional changes in the leukocytes are related to the mental states across the menstrual cycle in reproductive healthy female subjects. Thirty-eight female subjects (22.4 +/- 11.4 year-old) were participated in this study at three menstruation cycle periods (menstrual, follicular and luteal phase). The FKBP5 (FK506-binding protein gene), SERT (serotonin transporter gene) and COMT (catechol-o-methyltransferase gene) mRNA expressions in the leukocytes were determined with hormonal data. The psychological changes were assessed with self-rating hospital anxiety and depression scale (HADS). Only one thirds of subjects (n = 12) had regular menstrual cycles during the experiment. So we analyzed the data from these 12 subjects. The anxiety score of each subject was changed across the menstrual cycle (Friedman test: P < 0.05). The FKBP5 mRNA expression was significantly lower in the follicular phase than in the other phases but no changes were seen in either SERT or COMT mRNA expressions among the phases. In conclusion, there are differences of HADS anxiety score and FKBP5 mRNA expression in the leukocytes across the menstrual cycle but there is no correlation between anxiety scores and FKBP5 mRNA. (C) 2008 Elsevier Ireland Ltd. All rights reserved.