The anatomical relationships of the prefrontal cortex with limbic structures and the basal ganglia
The anatomical relationships of the prefrontal cortex with limbic structures and the basal ganglia
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DOI：
10.1177/026988119701100202
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发表时间：
1997-01-01
影响因子：
4.1
通讯作者：
Uylings, HBM
中科院分区：
文献类型：
--
作者：
Groenewegen, HJ;Wright, CI;Uylings, HBM
本文简要地讨论了解剖标准，已被用来划定前额叶皮层（PFC）的（前）运动皮层区在额叶。单一的解剖学标准，如细胞结构，与丘脑背内侧核或多巴胺能神经支配的连接，不足以明确定义PFC。有人认为，相对于一些结构方面，前额叶和（前）运动皮质区必须被视为一个连续体，而（功能）分化是基于额叶不同部分正在处理的信息类型。前额叶皮层和前运动皮层一样，参与了许多基底节-丘脑皮层回路，这一点也可以用同样的方式来解释。本文还总结了丘脑中线核/板内核、基底杏仁复合体和海马传入PFC-腹侧纹状体系统的组织结构。对大鼠的追踪研究结果表明，这些丘脑和边缘系统的输入在PFC和腹侧纹状体的水平上都表现出不同的会聚和分离模式。这导致的结论，PFC腹侧纹状体系统由一些较小的模块。
This paper briefly discusses the anatomical criteria that have been used to delineate the prefrontal cortex (PFC) from the (pre)motor cortical areas in the frontal lobe. Single anatomical criteria, such as cytoarchitecture, connectivity with the mediodorsal thalamic nucleus or a dopaminergic innervation, are insufficient to unequivocally define the PFC. It is argued that, with respect to a number of structural aspects, the prefrontal and the (pre)motor cortical areas must be viewed as a continuum, whereas a (functional) differentiation is based on the type of information that is being processed in different parts of the frontal lobe. The involvement of the PFC, like the premotor cortex, in a number of basal ganglia-thalamocortical circuits may be interpreted in the same way. The paper also summarizes the organization of the inputs from midline/intralaminar thalamic nuclei, the basal amygdaloid complex and the hippocampus into the PFC-ventral striatal system. The results of tracing studies in rats indicate that these thalamic and limbic inputs both at the level of the PFC and the ventral striatum show various patterns of convergence and segregation. This leads to the conclusion that the PFC-ventral striatal system consists of a number of smaller modules.