The functional integration of the anterior cingulate cortex during conflict processing
The functional integration of the anterior cingulate cortex during conflict processing
复制标题
DOI：
10.1093/cercor/bhm125
复制
发表时间：
2008-04-01
期刊：
影响因子：
3.7
通讯作者：
Posner, Michael I.
中科院分区：
文献类型：
--
作者：
Fan, Jin;Hof, Patrick R.;Posner, Michael I.
虽然前扣带皮层（ACC）与冲突处理相关的功能激活已经得到了广泛的研究，但在冲突条件下，ACC与其他大脑区域的细分功能整合仍不清楚。在这项研究中，参与者在使用事件相关功能磁共振成像扫描的同时，执行了一项旨在通过对目标反应的侧卫干扰来引发冲突处理的任务。利用心理生理相互作用分析和动态因果模型，分别考察了冲突处理与前扣带吻侧前部（RCZa）活动相互作用下，脑内多个区域的生理反应，以及该区域与其他区域之间的有效连接。在冲突和基线连接的主要影响之外，RCZa与ACC的尾状扣带区（CCZ）和其他大脑区域（如外侧前额叶、初级和辅助运动区）存在显著的整合。从RCZa到CCZ的内在连通性受到冲突上下文的调制。这些发现表明，冲突处理与RCZa对CCZ以及其他皮质区域的神经元活动的有效贡献有关。
Although functional activation of the anterior cingulate cortex (ACC) related to conflict processing has been studied extensively, the functional integration of the subdivisions of the ACC and other brain regions during conditions of conflict is still unclear. In this study, participants performed a task designed to elicit conflict processing by using flanker interference on target response while they were scanned using event-related functional magnetic resonance imaging. The physiological response of several brain regions in terms of an interaction between conflict processing and activity of the anterior rostral cingulate zone (RCZa) of the ACC, and the effective connectivity between this zone and other regions were examined using psychophysiological interaction analysis and dynamic causal modeling, respectively. There was significant integration of the RCZa with the caudal cingulate zone (CCZ) of the ACC and other brain regions such as the lateral prefrontal, primary, and supplementary motor areas above and beyond the main effect of conflict and baseline connectivity. The intrinsic connectivity from the RCZa to the CCZ was modulated by the context of conflict. These findings suggest that conflict processing is associated with the effective contribution of the RCZa to the neuronal activity of CCZ, as well as other cortical regions.