Artificial Pancreas System for Type 1 Diabetes—Challenges and Advancements
Artificial Pancreas System for Type 1 Diabetes—Challenges and Advancements
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治疗 1 型糖尿病的人工胰腺系统——挑战与进展
DOI：
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
S. Dhir
中科院分区：
文献类型：
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作者：
Sachit Kapil;R. Saini;S. Wangnoo;S. Dhir
1型糖尿病是一种慢性自身免疫性疾病，需要血糖监测和强化胰岛素治疗。其治疗管理旨在恢复正常的HbA1C，稳定餐后和餐后血糖水平。糖尿病患者自我管理的负担很高，对血糖测量设备的需求日益增长，这是一个挑战。这种装置可以持续监测葡萄糖浓度并自动调整胰岛素输送速率，从而有助于将血糖维持在健康范围内。人工胰腺系统（APS）技术在过去几年中发展迅速，能够提供有效的糖尿病管理，提高1型糖尿病患者的生活质量。本文综述了持续皮下胰岛素输注、数学模型、实时连续血糖监测和驱动闭环控制系统的控制算法等方面的APS技术的发展及其进展。本文还讨论了其局限性和提出的未来指令。
Type 1 diabetes mellitus is a chronic autoimmune disease, requiring glucose monitoring and intensive insulin therapy. Its therapeutic management aims to restore normal HbA1C and stabilize prandial and postprandial glucose levels. The burden of self-management of diabetes is high, and the growing requirement for blood glucose measuring devices presents a challenge. Such devices can continuously monitor glucose concentrations and automatically adjust insulin delivery rates, which in turn help to maintain blood glucose within a healthy range. The artificial pancreas system (so-called APS) technology has evolved rapidly over the past few years, capable of providing effective management of diabetes to improve quality of life of the type 1 diabetes mellitus patients. This review discusses the evolution of the APS technology and its progress in the various components: continuous subcutaneous insulin infusion, mathematical model, real-time continuous glucose monitoring, and control algorithms driving closed-loop control systems. The limitations and the proposed future directives are also discussed.