Peroxisomal beta-oxidation and polyunsaturated fatty acids
Peroxisomal beta-oxidation and polyunsaturated fatty acids
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DOI：
10.1111/j.1749-6632.1996.tb18612.x
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发表时间：
1996-01-01
期刊：
影响因子：
--
通讯作者：
Hayrinen, HM
中科院分区：
文献类型：
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作者：
Hiltunen, JK;Filppula, SA;Hayrinen, HM
过氧化体能够氧化多种底物，包括(多)不饱和烯醇-辅酶A酯。过氧化体和线粒体中不饱和的Enoyl-CoA酯的β-氧化作用不仅是链的缩短，而且还涉及到预先存在的碳-碳双键的代谢。除了β-氧化螺旋本身的酶外，这种代谢还需要辅助酶的参与：Delta 3，Delta 2-Enoyl-CoA异构酶；2，4-二烯酰-CoA还原酶；2-Ennoyl-CoA水合酶2或3-羟基酰辅酶A同分异构酶；以及Delta 3，5 Delta 2，4-Dienoyl-CoA异构酶。其中许多酶以异构体的形式存在，存在于多个亚细胞室中，如过氧化物体、线粒体或内质网，而其中一些活性是β-氧化系统多功能酶的组成部分。
Peroxisomes are capable of oxidizing a variety of substrates including (poly)unsaturated enoyl-CoA esters. The beta-oxidation of unsaturated enoyl-CoA esters in peroxisomes, and also in mitochondria, is not just chain-shortening but also involves the metabolizing of pre-existing carbon-to-carbon double bonds. In addition to the enzymes of the beta-oxidation spiral itself, this metabolism requires the participation of auxiliary enzymes: delta 3, delta 2-enoyl-CoA isomerase; 2,4-dienoyl-CoA reductase; 2-enoyl-CoA hydratase 2 or 3-hydroxyacyl-CoA epimerase; and delta 3,5 delta 2,4-dienoyl-CoA isomerase. Many of these enzymes are present as isoforms, and can be found located in multiple subcellular compartments, for example, peroxisomes, mitochondria or the endoplasmic reticulum, while some of the activities are integral parts of multifunctional enzymes of beta-oxidation systems.