Visualizing T Cell Migration in situ.
Visualizing T Cell Migration in situ.
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DOI：
10.3389/fimmu.2014.00363
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发表时间：
2014
影响因子：
7.3
通讯作者：
Khanna KM
中科院分区：
文献类型：
--
作者：
Benechet AP;Menon M;Khanna KM
建立保护性免疫反应在很大程度上依赖于淋巴组织内细胞的协调运动。次级淋巴器官的结构通过促进细胞-细胞和细胞-细胞外基质的最佳相互作用来调节免疫反应。原始T细胞最初由次级淋巴器官中的抗原提呈细胞激活。启动后，效应性T细胞迁移到感染部位以发挥其功能。大多数效应细胞死亡，而一小部分抗原特异性T细胞作为记忆细胞在不同的解剖位置持续存在。记忆细胞在淋巴组织和非淋巴组织中的持久性和定位是保护宿主免受再次感染的关键。记忆T细胞的定位受到多种因素的严格调控，包括高度组织化的次级淋巴结构、趋化因子受体的细胞表达以及同源配体的区间化分泌。这种解剖结构与细胞表面和可溶性蛋白有序表达之间的平衡，调节了T细胞迁移的微妙编排。近年来，随着新的成像技术的发展，我们对T细胞的细胞动力学有了更深入的了解，新的成像技术使我们能够原位观察T细胞的反应。在这里，我们回顾过去和最近的研究，利用先进的成像技术来研究幼稚T细胞、效应T细胞和记忆T细胞的迁移动力学。
Mounting a protective immune response is critically dependent on the orchestrated movement of cells within lymphoid tissues. The structure of secondary lymphoid organs regulates immune responses by promoting optimal cell–cell and cell–extracellular matrix interactions. Naïve T cells are initially activated by antigen presenting cells in secondary lymphoid organs. Following priming, effector T cells migrate to the site of infection to exert their functions. Majority of the effector cells die while a small population of antigen-specific T cells persists as memory cells in distinct anatomical locations. The persistence and location of memory cells in lymphoid and non-lymphoid tissues is critical to protect the host from re-infection. The localization of memory T cells is carefully regulated by several factors including the highly organized secondary lymphoid structure, the cellular expression of chemokine receptors and compartmentalized secretion of their cognate ligands. This balance between the anatomy and the ordered expression of cell surface and soluble proteins regulates the subtle choreography of T cell migration. In recent years, our understanding of cellular dynamics of T cells has been advanced by the development of new imaging techniques allowing in situ visualization of T cell responses. Here, we review the past and more recent studies that have utilized sophisticated imaging technologies to investigate the migration dynamics of naïve, effector, and memory T cells.
影响因子：
9.8
作者：
Witt CM;Raychaudhuri S;Schaefer B;Chakraborty AK;Robey EA
通讯作者：
Robey EA