Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target.
Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target.
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EZH2 在癌症干细胞中的作用：从生物学洞察到治疗靶点
DOI：
10.18632/oncotarget.16467
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发表时间：
2017-06-06
期刊：
影响因子：
--
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Wen Y;Cai J;Hou Y;Huang Z;Wang Z
Epigenetic modifications in cancer stem cells largely result in phenotypic and functional heterogeneity in many solid tumors. Increasing evidence indicates that enhancer of zeste homolog 2 (EZH2), the catalytic subunit of Polycomb repressor complex 2, is highly expressed in cancer stem cells of numerous malignant tumors and has a critical function in cancer stem cell expansion and maintenance. Here, we review up-to-date information regarding EZH2 expression patterns, functions, and molecular mechanisms in cancer stem cells in various malignant tumors and discuss the therapeutic potential of targeting EZH2 in tumors.
