Vitamin D, diet, and lifestyle in a chronic SCI population.
Vitamin D, diet, and lifestyle in a chronic SCI population.
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慢性 SCI 人群的维生素 D、饮食和生活方式。
DOI：
10.1038/s41393-018-0148-1
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发表时间：
2019
期刊：
影响因子：
2.2
通讯作者：
Garshick,Eric
中科院分区：
文献类型：
--
作者：
Koutrakis,NicholasE;Goldstein,RebekahL;Walia,Palak;Polak,MadelineM;Lazzari,AntonioA;Tun,CarlosG;Hart,JaimeE;Garshick,Eric
研究设计横断面研究。目的确定与慢性脊髓损伤 (SCI) 患者血浆 25-羟基维生素 D [25(OH)D] 水平相关的饮食、生活方式和临床因素。设置在马萨诸塞州波士顿退伍军人事务医疗中心。方法 174 名参与者完成了食物频率和健康调查问卷，提供了血液样本，并接受了双重 X 射线检查 吸收测定法 (DXA) 用于评估全身脂肪百分比。使用线性回归模型评估个人、生活方式和营养因素与血浆 25(OH)D 的横断面关联。结果与较高血浆 25(OH)D 呈正相关的独立因素包括维生素 D 摄入量、年龄、计划运动时间、女性、白种人、饮酒以及是否从未吸烟或以前吸烟。 25(OH)D 最重要的预测因素是补充剂摄入量。大多数受试者（98.9% 的维生素 D 和 74.1% 的钙）仅从饮食中未能达到成人建议的每日摄入量。 SCI 的水平和完整性、损伤持续时间、活动能力、总脂肪百分比、户外时间和合并疾病与血浆 25(OH)D 无关。结论 慢性 SCI 中的血浆 25(OH)D 水平与 SCI 特有的临床因素（如损伤程度和完整性、损伤持续时间和活动模式）无关，但与补充剂摄入量和其他生活方式因素相关。
Study designCross-sectional study.ObjectivesDetermine dietary, lifestyle, and clinical factors associated with plasma 25-hydroxyvitamin D [25(OH)D] levels in persons with chronic spinal cord injury (SCI).SettingVeterans Affairs Medical Center in Boston, MA.Methods174 participants completed food frequency and health questionnaires, provided a blood sample, and underwent dual x-ray absorptiometry (DXA) to assess %total body fat. Linear regression models were used to assess cross-sectional associations of personal, lifestyle, and nutritional factors with plasma 25(OH)D.ResultsIndependent factors positively associated with higher plasma 25(OH)D included vitamin D intake, age, hours of planned exercise, female sex, white race, wine consumption, and if a never or former smoker. The most important predictor of 25(OH)D was supplement intake. The majority of subjects (98.9% for vitamin D and 74.1% for calcium) did not meet the recommended daily allowance for adults from their diet alone. Level and completeness of SCI, injury duration, mobility, %total body fat, time outside, and comorbid diseases were not associated with plasma 25(OH)D.ConclusionsPlasma 25(OH)D level in chronic SCI is not associated with clinical factors specific to SCI such as injury level and completeness, injury duration, and mobility mode, but related to supplement intake and other lifestyle factors.