TONOTOPIC ORGANIZATION, ARCHITECTONIC FIELDS, AND CONNECTIONS OF AUDITORY-CORTEX IN MACAQUE MONKEYS
TONOTOPIC ORGANIZATION, ARCHITECTONIC FIELDS, AND CONNECTIONS OF AUDITORY-CORTEX IN MACAQUE MONKEYS
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DOI：
10.1002/cne.903350312
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发表时间：
1993-09-15
影响因子：
2.5
通讯作者：
KAAS, JH
中科院分区：
文献类型：
--
作者：
MOREL, A;GARRAGHTY, PE;KAAS, JH
用微电极记录法研究了猕猴听皮层的音调定位结构，并指导了麦胚凝集素-辣根过氧化物酶（WGA-HRP）和荧光染料的注射位置。解剖学和生理学的结果，后来相关的组织学的区别，在相同的大脑切片后，处理细胞结构，骨髓结构，乙酰胆碱酯酶（AchE），或细胞色素氧化酶（CO）。这些实验产生了几个主要的发现。(1)在大脑皮层的广阔区域，神经元对纯音的反应都很灵敏，而且在一系列的记录点上，神经元的最佳频率也可以确定。(2)微电极记录揭示了两个系统的代表性的音调频率，初级区（AI）和初级样喙场（R），如前所述。在A1中，高到低频率音调的表示主要是沿着沟平面的尾侧沿着。在R. (3)AI和R一起coextensive与koniocellular，密集的髓鞘区，表达高水平的乙酰胆碱酯酶和CO。这些架构功能有点不太明显，在R比AI，但两个领域之间的明确边界并不明显。(4)与AI和R交界的皮层对音调的反应较弱，但当神经元的最佳频率可以确定时，它们与AI和R相邻部分的频率相匹配。(5)在与AI和R交界的一些皮层中，明显存在结构上不同的区域。(6)AI的同侧皮质连接主要是与R和AI外侧和内侧的皮质。(7)AI的胼胝体连接主要与对侧AI的匹配位置，但也包括相邻的领域。(8)内侧膝状体复合体的腹侧（MG（V））、内侧（MG（M））和背侧（MG（D））核中的神经元投射到AI和AI外侧的皮质。(9)高频声刺激的皮层注射液比低频声刺激的皮层注射液标记更多的MG（V）背侧部分。 (C)1993 Wiley-Liss，Inc.
Microelectrode recordings were used to investigate the tonotopic organization of auditory cortex of macaque monkeys and guide the placement of injections of wheat germ agglutinin-horse radish peroxidase (WGA-HRP) and fluorescent dyes. Anatomical and physiological results were later related to histological distinctions in the same brains after sections were processed for cytoarchitecture, myeloarchitecture, acetylcholinesterase (AchE), or cytochrome oxidase (CO). The experiments produced several major findings. (1) Neurons throughout a broad expanse of cortex were highly responsive to pure tones, and best frequencies could be determined for neurons in arrays of recording sites. (2) The microelectrode recordings revealed two systematic representations of tone frequencies, the primary area (AI) and a primary-like rostral field (R) as previously described. The representation of high to low frequency tones in A1 was largely caudorostral along the plane of the sulcus. A reversal of the order of representation of frequencies occurred in R. (3) AI and R together were coextensive with a koniocellular, densely myelinated zone that expressed high levels of AchE and CO. These architectonic features were somewhat less pronounced in R than AI, but a clear border between the two areas was not apparent. (4) Cortex bordering AI and R was less responsive to tones, but when best frequencies for neurons could be determined, they matched those for adjoining parts of AI and R. (5) Architectonically distinct regions were apparent within some of the cortex bordering AI and R. (6) The major ipsilateral cortical connections of AI were with R and cortex immediately lateral and medial to AI. (7) Callosal connections of AI were predominately with matched locations in the opposite AI, but they also included adjoining fields. (8) Neurons in the ventral (MG(V)), medial (MG(M)), and dorsal (MG(D)) nuclei of the medial geniculate complex projected to AI and cortex lateral to AI. (9) Injections in cortex responsive to high frequency tones labeled more dorsal parts of MG(V) than injections in cortex responsive to low frequency tones. (C) 1993 Wiley-Liss, Inc.