A thermal-ablation bioheat model including liquid-to-vapor phase change, pressure- and necrosis-dependent perfusion, and moisture-dependent properties
A thermal-ablation bioheat model including liquid-to-vapor phase change, pressure- and necrosis-dependent perfusion, and moisture-dependent properties
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DOI：
10.1016/j.ijheatmasstransfer.2006.11.045
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发表时间：
2007-07-01
影响因子：
5.2
通讯作者：
Sparrow, E. M.
中科院分区：
文献类型：
--
作者：
Abraham, J. P.;Sparrow, E. M.
一种新的生物热模型被应用于评估高温热疗对病变组织的非手术消融的使用。这个新的模型是基于使用焓方法来解释液-汽相变的。此外，该模型还包括热物理性质对液体含量的依赖，以及血液灌注率的变化依赖于组织的局部坏死状态或治疗输送装置施加的外部压力。该模型特别适用于治疗月经过多的子宫内膜消融术。该模型的实施结果得出了与在暴露的子宫组织内表面施加给定的热相对应的组织坏死深度。这些结果明确地确立了相变的发生和完全的灌注抑制是控制坏死深度的主要因素。水分相关特性的计算对坏死率的影响可以忽略不计。(C)2007爱思唯尔有限公司。保留所有权利。
A new bioheat model is applied to evaluate the use of elevated-temperature thermal therapies for the non-surgical ablation of diseased tissue. The new model is based on the use of the enthalpy method to account for liquid-to-vapor phase change. In addition, the model includes thermophysical property dependence on liquid content and variations of blood perfusion rates dependent on the local necrotic state of the tissue or external pressure applied by the therapy-delivering device. This model is applied here specifically to endometrial ablation for the treatment of menorrhagia. The results of the implementation of the model yielded the depth of tissue necrosis corresponding to a given application of heat at the exposed inner surface of the uterine tissue. These results definitively establish the occurrence of phase change and the complete suppression of perfusion as the major factors governing the necrosis depth. The accounting of moisture-dependent properties had a negligible effect on necrosis. (C) 2007 Elsevier Ltd. All rights reserved.