Hepatitis C infection: a rare cause of fulminant hepatic failure.
Hepatitis C infection: a rare cause of fulminant hepatic failure.
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丙型肝炎感染：暴发性肝衰竭的罕见原因。
DOI：
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发表时间：
1995
影响因子：
9.8
通讯作者：
C. Trey
中科院分区：
文献类型：
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作者：
Gordon Fd;H. Anastopoulos;U. Khettry;M. Loda;R. Jenkins;W. Lewis;C. Trey
暴发性肝功能衰竭是由多种病毒、毒素和代谢紊乱引起的。丙型肝炎病毒(丙型肝炎病毒)可导致慢性肝硬变，且与暴发性肝功能衰竭无关。我们报告了美国第一例记录在案的暴发型丙型肝炎病例。患者出现黄疸和IV期脑病。初步的实验室评估没有揭示病因。患者在没有肝移植的情况下存活了下来。三周后，他被发现有阳性的丙型肝炎病毒核糖核酸和抗丙型肝炎病毒抗体血清转换。他在接受α-干扰素治疗后继续好转，15个月后肝功能正常，丙型肝炎病毒RNA阴性。
Fulminant hepatic failure is caused by a variety of viruses, toxins, and metabolic derangements. The hepatitis C virus (HCV) causes indolent development of cirrhosis and has not been associated with fulminant hepatic failure. We report the first documented case of fulminant hepatitis C in the United States. The patient developed jaundice and stage IV encephalopathy. Initial laboratory evaluation did not reveal the etiology. The patient survived without liver transplantation. Three wk later he was found to have a positive HCV RNA and anti-HCV antibody seroconversion. He continued to improve with alpha-interferon treatment and has normal liver function and a negative HCV RNA 15 months later.