Impact of dosage frequency on patient compliance
Impact of dosage frequency on patient compliance
复制标题
DOI：
10.2337/diacare.20.10.1512
复制
发表时间：
1997-10-01
期刊：
影响因子：
16.2
通讯作者：
SoeAgnie, CJ
中科院分区：
文献类型：
--
作者：
Paes, AHP;Bakker, A;SoeAgnie, CJ
目的 - 评估剂量频率对 PaRESEARCH 设计和方法依从性的影响 - 每个月，患者都会收到装在药物事件监测系统容器中的药物，该系统会记录每次打开包装的情况。研究结束时，患者收到一份简短的调查问卷。受试者为 91 名使用口服降糖药的糖尿病患者。服用胰岛素的患者和无法从药房领取药物的患者被排除在研究之外。依从性定义为观察期间服用剂量的百分比。使用的另一个参数是对处方方案的依从性，定义为按处方服用药片数量的天数百分比。作为最后一个参数。结果 - 依从性受到剂量频率的影响。这组患者的依从性为 74.8%，每日一次剂量的平均依从性为 79%，每日三次剂量的依从性为 38%。所有组中不依从性的主要类型是剂量遗漏。然而，超过三分之一的患者使用的剂量超过了处方剂量。过量服用是患者在每天服用一剂的方案中经常犯的错误。结论 - 减少剂量频率可能会减少总体不依从性，但同时也会增加过量服用的风险。减少频率并不会自动产生更好的治疗方案。每日一次或两次的选择应取决于药物的治疗范围。
OBJECTIVE - To evaluate the impact of dosage frequency on the compliance of paRESEARCH DESIGN AND METHODS - Each month, patients received a supply of their medication in a Medication Event Monitoring Systems container, which registered each opening of the package. Ar the end of the study the patients received a short questionnaire. The subjects were 91 diabetic patients using oral antidiabetic agents. Patients taking insulin and those who were unable to collect their medicines from the pharmacy were excluded from the study. Compliance was defined as the percentage of doses taken during the observation period. Another parameter used was compliance with the prescribed regimen, defined as the percentage of days in which the number of tablets were taken as prescribed. As a last parameter. compliance with the prescribed dose intervals was used.RESULTS - Compliance is influenced by the frequency of doses. The compliance for this group of patients is 74.8%, with an average of 79% in the case of a dose once daily and 38% in the case of a dose three times daily The predominant type of noncompliance in all groups was dose omissions. However, more than one-third of the patients used more doses than prescribed. Overconsumption is a frequently made mistake by patients on a one-dose daily schedule.CONCLUSIONS - The reduction of dose frequency may decrease total noncompliance, but at the same time, it increases the risk of overconsumption. Reducing the frequency does not automatically result in a better therapeutic schedule. The choice of once or twice daily should depend on the therapeutic range of the drug.