CORRELATIONS BETWEEN UNIT FIRING AND EEG IN THE RAT OLFACTORY SYSTEM
CORRELATIONS BETWEEN UNIT FIRING AND EEG IN THE RAT OLFACTORY SYSTEM
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DOI：
10.1016/0006-8993(90)91663-2
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发表时间：
1990-10-01
期刊：
影响因子：
2.9
通讯作者：
FREEMAN, WJ
中科院分区：
文献类型：
--
作者：
EECKMAN, FH;FREEMAN, WJ
清醒动物的嗅觉EEG在γ-射线中显示出活动的振荡爆发。（30-100 Hz）范围。爆发与鼻子中感受器层上方的空气流入相关。显示这些振荡的皮层的输入中没有一个携带γ-γ中的周期性信号。范围因此，这些爆发是局部产生的，无论是通过神经元的反馈相互作用或振荡神经元的耦合。在第一种情况下，如果振荡是由负反馈产生的，那么必须存在两类细胞：兴奋性神经元和抑制性神经元，它们具有相同的振荡频率，但抑制性细胞的相位滞后于兴奋性细胞。另一方面，如果EEG是由固有振荡的细胞的耦合产生的，则应该存在相位值的宽而单峰的分布。为了确定这些爆发的起源，我们在清醒和激励大鼠的嗅觉系统的4个部分（嗅球，前嗅核，梨状前皮质和外侧内嗅区）进行同步记录EEG和多单位棘波。对于每个样本，从相同的局部邻近区域记录EEG和多单位尖峰。多单元电极记录来自各个皮层区域的主要输出神经元的脉冲。在所有测试的位置，脉冲概率或发射的振荡被发现具有相同的频率作为主导EEG频率。在这4个结构中，我们发现了两组细胞，一组细胞显示的脉冲与EEG同相，另一组细胞显示的脉冲超前或滞后EEG约1/4个周期。这些数据证实了负反馈相互作用模型，而不是耦合振荡器模型产生的爆发在嗅觉系统。这些发现的相关性，以其他皮质系统，在casu的视觉皮层进行了讨论。
The olfactory EEG of awake animals displays oscillatory bursts of activity in the .gamma.- (30-100 Hz) range. The bursts are correlated with inflow of air over the receptor layer in the nose. None of the inputs to the cortices that display these oscillations carries periodic signals in the .gamma.-range. Thus these bursts are generated locally, either by neuronal feedback interactions or by coupling of oscillatory neurons. In the first case if the oscillations are generated by negative feedback, then two classes of cells must exist: excitatory neurons and inhibitory neurons with the same frequency of oscillation but with a quarter cycle phase lag by the inhibitory cells from the excitatory cells. On the other hand, if the EEG''s result from coupling of cells that are intrinsically oscillatory, there should be a broad but monomodal distribution of phase values. In order to determine the origin of these bursts, we performed simultaneous recordings of EEG and multi-unit spikes in the 4 parts of the olfactory system (olfactory bulb, anterior olfactory nucleus, prepyriform cortex and lateral entorhinal area) of awake and motivated rats. For each sample, the EEG and the multi-unit spikes were recorded from the same local neighborhood. The multi-unit electrode recorded pulses from the principal output neurons of the respective cortical areas. In all locations tested, the oscillations in pulse probabilities or firing were found to have the same frequency as the dominant EEG frequency. In all 4 structures two sets of cells were found. One set displayed pulses in phase with the EEG and the other set displayed pulses that led or lagged the EEG by approximately 1/4 cycle. These data confirm the negative feedback interaction model rather than the coupled oscillator model for the generation of the bursts in the olfactory system. The relevance of these findings to other cortical systems, in casu the visual cortex is discussed.