Age, gender, biometry, refractive error, and the anterior chamber angle among Alaskan Eskimos
Age, gender, biometry, refractive error, and the anterior chamber angle among Alaskan Eskimos
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DOI：
10.1016/s0161-6420(02)01748-7
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发表时间：
2003-02-01
期刊：
影响因子：
13.7
通讯作者：
Broman, AT
中科院分区：
文献类型：
--
作者：
Wojciechowski, R;Congdon, N;Broman, AT
背景：爱斯基摩人/因纽特人的闭角型青光眼(ACG)患病率高于世界上任何其他民族。虽然这一流行可能是由于人群倾向于较浅的前房角，但现有的证据在其他人群，如中国人，ACG发生率较高的人群中并没有一致地显示出这种趋势。方法：根据先前报道的生物角化检查(BG)的方案，使用网纹、裂隙灯和标准Goldmann一镜房角来测量前房(AC)角(眼科学，1999年；106：2161-7)。对133名40岁及以上的阿拉斯加爱斯基摩人的一只眼睛的四个象限进行了测量。对所有受试者进行自动屈光、眼前节和视神经扩张检查，以及AC深度、晶状体厚度和眼轴长度的A超测量。结果：在相同方案下，爱斯基摩受试者的中心和外周AC测量值均显著低于我们报道的中国人、黑人和白人。爱斯基摩人似乎也有更多的远视。在这群爱斯基摩人中，男性和女性之间的生物测量没有差异。在爱斯基摩人和中国人的一生中，BG测量的角度似乎比黑人或白人下降得更快。虽然在爱斯基摩人中，随着年龄的增长，AC深度明显减少，晶状体厚度增加，远视增加，但所有这些趋势在70年代及以后似乎都逆转了。结论：爱斯基摩人的ACS似乎确实比其他种族的人浅。在爱斯基摩人中，AC角的测量在一生中似乎比黑人或白人下降得更快，我们在另一个ACG患病率较高的中国人中也观察到了这一现象。这种明显的更快的下降可能是由于队列效应，近视的患病率更高，导致年轻的爱斯基摩人和中国人的角度更宽。眼科2003；美国眼科学会110：365-375(C)2003。
Background: The prevalence of angle-closure glaucoma (ACG) is greater for Eskimos/Inuit than it is for any other ethnic group in the world. Although it has been suggested that this prevalence may be due to a population tendency toward shallower anterior chamber angles, available evidence for other populations such as Chinese with high rates of ACG has not consistently demonstrated such a tendency.Methods: A reticule, slit-lamp, and standard Goldmann one-mirror goniolens were used to make measurements in the anterior chamber (AC) angle according to a previously reported protocol for biometric gonioscopy (BG) (Ophthalmology 1999;106:2161-7). Measurements were made in all four quadrants of one eye among 133 phakic Alaskan Eskimos aged 40 years and older. Automatic refraction, dilated examination of the anterior segment and optic nerve, and A-scan measurements of AC depth, lens thickness, and axial length were also carried out for all subjects.Results: Both central and peripheral AC measurements for the Eskimo subjects were significantly lower than those previously reported by us for Chinese, blacks, and whites under the identical protocol. Eskimos also seemed to have somewhat more hyperopia. There were no differences in biometric measurements between men and women in this Eskimo population. Angle measurements by BG seemed to decline more rapidly over life among Eskimos and Chinese than blacks or whites. Although there was a significant apparent decrease in AC depth, increase in lens thickness, and increase in hyperopia with age among Eskimos, all of these trends seemed to reverse in the seventh decade and beyond.Conclusions: Eskimos do seem to have shallower ACs than do other racial groups. Measurements of the AC angle seem to decline more rapidly over life among Eskimos than among blacks or whites, a phenomenon also observed by us among Chinese, another group with high ACG prevalence. This apparent more rapid decline may be due to a cohort effect with higher prevalence of myopia and resulting wider angles among younger Eskimos and Chinese. Ophthalmology 2003;110:365-375 (C) 2003 by the American Academy of Ophthalmology.