LIPOSOME TOXICITY IN MOUSE CENTRAL NERVOUS-SYSTEM
LIPOSOME TOXICITY IN MOUSE CENTRAL NERVOUS-SYSTEM
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DOI：
10.1016/0022-510x(77)90104-6
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发表时间：
1977-01-01
影响因子：
4.4
通讯作者：
WISNIEWSKI, HM
中科院分区：
文献类型：
--
作者：
ADAMS, DH;JOYCE, G;WISNIEWSKI, HM
虽然一些脂质体对中枢神经系统有很高的毒性，但其他不同成分的脂质体在所用剂量(0.02-0.05 mg.ident)下耐受性良好。4-12毫克脂肪/接种剂)。那些由卵磷脂-胆固醇-二乙基磷酸或卵磷脂-胆固醇-硬脂胺组成的化合物在注射后立即引起全身性癫痫发作和一些因呼吸衰竭而死亡，以及随后广泛的组织坏死。由卵磷脂-胆固醇-磷脂酸或二棕榈酰卵磷脂组成的脂质体仅产生最小的形态变化，到注射后第6天，病理仅限于注射造成的机械损伤。适当组成的脂质体可能是足够良性的，可以用作治疗药物进入中枢神经系统的载体。
While some liposomes are highly toxic to the CNS, others, of different compositions, are tolerated well in the dosage used (0.02-0.05 mg .ident. 4-12 mg of lipid/inoculum). Those composed of lecithin-cholesterol-dicetyl phosphate or lecithin-cholesterol-stearylamine produced generalized epileptic seizures and some deaths due to respiratory failure immediatley after injection, and a subsequent widespread tissue necrosis. Liposomes composed of lecithin-cholesterol-phosphatidic acid, or dipalmitoyl lecithin only, produced minimal morphological changes and by the 6th day post-injection the pathology was limited to the mechanical trauma caused by the injection. Liposomes of appropriate composition may be sufficiently benign to use as carriers of therapeutic agents into the CNS.