Turning the Heat on Cancer
Turning the Heat on Cancer
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DOI：
10.1089/cbr.2008.0591
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发表时间：
2008-12-01
影响因子：
3.4
通讯作者：
DeNardo, Sally J.
中科院分区：
文献类型：
--
作者：
DeNardo, Gerald L.;DeNardo, Sally J.
热疗的前景尚未实现，但其基本思想和热对（癌）细胞的影响是众所周知的。暴露于热的细胞死亡是热强度和暴露时间的函数。细胞通过坏死和凋亡而死亡。亚致死热剂量使癌细胞对辐射和药物敏感。由于化学和物理学的进步，利用热的力量杀死癌细胞现在似乎是可以实现的！使用体现在分子靶向纳米颗粒和具有“聚焦”交变磁频率（AMF）的纳米颗粒的滞后加热的组合中的新型系统，可以更好地控制热传递。重要的是，高温不会损害，实际上可能会增强免疫系统。需要在患者中进行试验，以确定新的热治疗的临床作用。
The promise of hyperthermia has yet to be realized, but the fundamental idea and the effects of heat on (cancer) cells are well known. Cell death from exposure to heat is a function of both the intensity of the heat and the length of the exposure. Cells die by necrosis and by apoptosis. Sublethal heat doses sensitize cancer cells to radiation and drugs. Because of advances in chemistry, and physics, harnessing the power of heat to kill cancer cells seems achievable now! Using novel systems embodied in the combination of molecular-targeted nanoparticles and hysteretic heating of the nanoparticles with "focussed" alternating magnetic frequencies (AMFs), heat delivery can be better controlled. Importantly, hyperthermia does not damage, and may actually enhance, the immune system. Trials in patients are needed to settle the clinical role of new thermal treatment.