Receptor-stimulated actin polymerization requires cytoplasmic acidification in human PMNs.
Receptor-stimulated actin polymerization requires cytoplasmic acidification in human PMNs.
复制标题
受体刺激的肌动蛋白聚合需要人类中性粒细胞的细胞质酸化。
DOI：
10.1016/0167-4889(90)90236-7
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Niederman,R
中科院分区：
文献类型：
--
作者：
Tonetti,M;Budnick,M;Niederman,R
Cytoplasmic alkalinization has received considerable attention as a regulatory event In cell growth, transformation and signal transduction (Busa, W.B. (1986) Annu. Rev. Physiol. 48, 389–402 and Moolenar, W.H. (1986) Annu. Rev. Physiol. 48, 363–376). In contrast the current paper presents evidence for the role of an early cytoplasmic acidification, during signal transduction in the polymorphonuclear leukocyte (PMN). Following PMN stimulation with a chemotactic peptide, there is a significant decrease in cytoplasmic pH concomitant with a dramatic increase in cytoskeletal actin. The data indicate that this drop in pHiis necessary, but not sufficient, for signal transduction leading to cytoskeletal reorganization in these cells.
