DRUG-INDUCED INHIBITION OF PLATELET FUNCTION DELAYS PROGRESSION OF PERIPHERAL OCCLUSIVE ARTERIAL DISEASE A Prospective Double-Blind Arteriographically Controlled Trial
DRUG-INDUCED INHIBITION OF PLATELET FUNCTION DELAYS PROGRESSION OF PERIPHERAL OCCLUSIVE ARTERIAL DISEASE A Prospective Double-Blind Arteriographically Controlled Trial
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药物诱导的血小板功能抑制可延缓外周闭塞性动脉疾病的进展一项前瞻性双盲动脉造影对照试验
DOI：
10.1016/s0140-6736(85)91144-4
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
G. Deichsel
中科院分区：
文献类型：
--
作者：
H. Hess;A. Mietaschk;G. Deichsel
240名患者接受了一项双盲研究，以确定长期使用血小板功能抑制药治疗下肢闭塞性动脉疾病的效果。患者被随机分成三组中的一组：阿司匹林330毫克；潘生丁75毫克和阿司匹林330毫克；或匹配的安慰剂，每天3次。疗程2年。动脉造影术在研究开始时进行，如果观察到恶化，则在2年后或之前进行。199名患者按照试验方案完成研究。采用简单对比观察的方法对系列动脉造影进行定性评价，并采用Bollinger评分系统进行半定量评价。疾病的进展在安慰剂治疗组最明显，在阿司匹林治疗组不那么明显，最不明显的是潘生丁和阿司匹林组。吸烟患者和高血压患者可能从研究中的两种制剂的治疗中受益最多。
240 patients were admitted to a double-blind study to determine the effect of long-term treatment with platelet-function inhibiting agents on occlusive arterial disease in the lower extremities. Patients were randomised into 1 of 3 treatment groups: aspirin 330 mg; dipyridamole 75 mg and aspirin 330 mg; or matching placebo 3 times daily. The duration of treatment was 2 years. Arteriography was carried out at the beginning of the study and 2 years later or before if deterioration was observed. 199 patients completed the study according to the trial protocol. The serial arteriograms were assessed in pairs qualitatively, by means of simple comparative viewing, and semiquantitatively with Bollinger's score system. Progression of the disease was most pronounced in the placebo-treated group, less so in the aspirin-treated group, and least of all in the dipyridamole-and-aspirin group. Patients who smoke and those with hypertension may benefit most from treatment with the 2 preparations under investigation.