Predictors of reduced health-related quality of life in adults with coeliac disease
Predictors of reduced health-related quality of life in adults with coeliac disease
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DOI：
10.1111/j.1365-2036.2006.03227.x
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发表时间：
2007-03-01
影响因子：
7.6
通讯作者：
Stein, J.
中科院分区：
文献类型：
--
作者：
Hauser, W.;Stallmach, A.;Stein, J.
背景 关于乳糜泻健康相关生活质量下降的预测因素的可用数据并不一致。目的 通过多变量方法测试文献中描述的健康相关生活质量下降的预测因素。方法 德国乳糜泻协会的 1000 名成年乳糜泻患者在邮寄调查中完成了医学和社会人口学调查问卷、简式健康调查 (SF-36)、乳糜泻问卷和医院焦虑和抑郁量表。通过逻辑回归分析测试健康相关生活质量下降的预测因子。 结果 身体合并症（β = -0.41；OR = 0.66，P < 0.001）和精神障碍（β = 0.88；OR = 2.4，P = 0.03）与 SF-36 身体总结评分降低相关。精神障碍（β = 2.5；OR = 11.9，P < 0.001）、躯体合并症（β = -0.26；OR = 0.77，P = 0.004）和诊断时年龄较小（β = -0.10；OR = 0.91，P = 0.05）预测 SF-36 心理总分会降低。精神障碍（β = 0.90；OR = 2.5，P = 0.03）、不遵守无麸质饮食（β = 0.44；OR = 1.6，P = 0.009）、活动性医疗合并症（β = -0.28；OR = 0.76，P = 0.007）以及对医患沟通的不满（β = 0.55；OR = 1.7，P = 0.03）与乳糜泻问卷评分降低相关。结论 乳糜泻患者健康相关生活质量下降不仅与身体和精神合并症有关，还与不遵守无麸质饮食和对医患沟通不满意有关。
Background Data available on predictors of reduced health-related quality of life in coeliac disease are not consistent. Aim To test predictors of reduced health-related quality of life, described in the literature, by a multivariate approach.Methods 1000 adult coeliacs of the German Coeliac Society completed a medical and a sociodemographic questionnaire, the Short-Form Health Survey (SF-36), the Coeliac Disease Questionnaire and the Hospital Anxiety and Depression Scale within a postal survey. Predictors of reduced health-related quality of life were tested for by logistic regression analysis.Results Physical comorbidities (beta = -0.41; OR = 0.66, P < 0.001) and mental disorder (beta = 0.88; OR = 2.4, P = 0.03) were associated with a reduced physical summary score of the SF-36. Mental disorder (beta = 2.5; OR = 11.9, P < 0.001), physical comorbidities (beta = -0.26; OR = 0.77, P = 0.004) and younger age at diagnosis (beta = -0.10; OR = 0.91, P = 0.05) predicted a reduced mental summary score of the SF-36. Mental disorder (beta = 0.90; OR = 2.5, P = 0.03), non-compliance with gluten-free diet (beta = 0.44; OR = 1.6, P = 0.009), active medical comorbidities (beta = -0.28; OR = 0.76, P = 0.007) and dissatisfaction with doctor-patient communication (beta = 0.55; OR = 1.7, P = 0.03) were associated with reduced Coeliac Disease Questionnaire scores. Conclusions Reduced health-related quality of life in coeliac disease is associated not only with physical and mental comorbidities, but also with non-compliance with gluten-free diet and dissatisfaction with doctor-patient communication.