Downregulation of MicroRNA-1 is Associated with Poor Prognosis in Hepatocellular Carcinoma.
Downregulation of MicroRNA-1 is Associated with Poor Prognosis in Hepatocellular Carcinoma.
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DOI：
10.7754/clin.lab.2015.150319
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发表时间：
2015
影响因子：
0.7
通讯作者：
Xuanyi Wang;Yuxiang Huang;H. Zhuang;Yayun Qian;Qiusheng Zhao;Lin Yang;Hao Gu;Jue Chen;R. Guo;Yanqing Liu
中科院分区：
文献类型：
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作者：
Xuanyi Wang;Yuxiang Huang;H. Zhuang;Yayun Qian;Qiusheng Zhao;Lin Yang;Hao Gu;Jue Chen;R. Guo;Yanqing Liu
BACKGROUND The relationship between microRNA-1 (miR-1) expression and prognosis has not been reported in hepatocellular carcinoma (HCC). The present study aimed to explore the clinicopathological significance and the prognostic role of miR-1 in HCC. METHODS The expression levels of miR-1 were quantified using real-time quantitative PCR (q-PCR) in 40 surgically resected HCC samples and matched adjacent non-cancerous tissues. RESULTS MiR-1 expression was significantly downregulated in HCC compared with matched non-cancerous tissues. Aberrant miR-1 expression was significantly correlated with gender, expression of hepatitis B virus surface antigen (HBsAg), tumor differentiation, vein invasion, and TNM stage. Patients with low expression of miR-1 had significantly reduced overall survival compared with patients with high expression of miR-1 (p = 0.04).The multivariate Cox regression analysis indicated that miR-1 expression (HR = 2.79; p = 0.005), gender (HR = 0.087; p = 0.005), vein invasion (HR = 0.172; p = 0.007), and TNM stage (HR = 3.421; p = 0.001) were independent prognostic factors for overall survival. CONCLUSIONS Low miR-1 expression is associated with shortened survival time. MiR-1 may act as a potential prognostic biomarker for HCC patients.
