Salt preference in the preweaning rat.
Salt preference in the preweaning rat.
复制标题
断奶前大鼠的盐偏好。
DOI：
10.1002/dev.420200408
复制
发表时间：
1987
影响因子：
2.2
通讯作者：
Courtney,L
中科院分区：
文献类型：
--
作者：
Bernstein,IL;Courtney,L
使用激发独立摄食反应的方法检查5-20日龄大鼠的盐（NaCl）偏好。将大鼠置于温暖潮湿的培养箱中，铺上毛巾，毛巾用水或供试品溶液饱和。观察到主动吸吮反应，其指向用溶液浸泡的毛巾，并将25分钟测试中的体重增加作为摄入指数。在大多数年龄的幼崽喜欢高渗盐水溶液的水，在10日龄的大鼠似乎特别不敏感的厌恶浓缩（4-8%）氯化钠溶液。与10、15和20日龄大鼠相比，5日龄大鼠从不喜欢NaCl溶液而不是水，并且避免使用老年大鼠喜欢的浓度。这种模式的NaCl偏好不能很容易地解释在已知的增加敏感性的大鼠的味觉系统的NaCl刺激与年龄。还检查了NH 4Cl溶液的摄入，并且在10日龄时，对浓缩NH 4Cl溶液的显著偏好是明显的，这与年龄较大的幼鼠和成年大鼠在使用NH 4Cl溶液时的行为形成鲜明对比。本文还讨论了鼓索和孤束核的电生理数据与本研究结果的关系。
Salt (NaCl) preference of 5–20‐day‐old rats was examined using a method which elicits independent ingestive responses. Rats were placed in a warm, moist incubator on toweling which was saturated with water or test solutions. Active mouthing responses were seen which were directed toward the towel soaked with solution and weight gain in a 25‐min test was taken as an index of ingestion. At most ages pups preferred hypertonic saline solutions to water and at 10 days of age rats appeared particularly insensitive to the aversiveness of concentrated (4–8%) NaCl solutions. In contrast to the 10‐, 15‐, and 20‐day‐old rats, the 5‐day‐old rats never preferred NaCl solutions to water and avoided them at concentrations which older rats preferred. This pattern of NaCl preference cannot easily be explained in terms of the known increases in sensitivity of the rat's taste system to NaCl stimulation with age. Ingestion of NH4Cl solutions was also examined and at 10 days of age significant preference for concentrated NH4Cl solutions was evident which contrasts markedly with the behavior of older pups and adult rats when presented with NH4Cl solutions. The relationship between the present findings and available electrophysiological data from the chorda tympani and nucleus of the solitary tract are discussed.