Serum C-reactive protein as independent prognostic variable in patients with ovarian cancer
Serum C-reactive protein as independent prognostic variable in patients with ovarian cancer
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DOI：
10.1158/1078-0432.ccr-07-1044
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发表时间：
2008-02-01
影响因子：
11.5
通讯作者：
Reinthaller, Alexander
中科院分区：
文献类型：
--
作者：
Hefler, Lukas A.;Concin, Nicole;Reinthaller, Alexander
目的：探讨血清C反应蛋白（CRP）作为上皮性卵巢癌（EOC）患者预后指标的价值。实验设计：在一项多中心研究中，对623例EOC患者术前血清CRP进行评估。结果：术前平均（SD）血清CRP为3.6（4.8）mg/dL。血清CRP水平与国际妇产科医师联合会临床分期显著相关（P < 0.001）和术后残留瘤块而与组织学分级无关（P = 0.1）和类型（P = 0.7）、患者年龄（Pearson相关系数= 0.05; P = 0.2）和血清CA 125（Pearson相关系数= 0.02; P = 0.6）。铂类耐药EOC患者的CRP血清水平显著高于铂类敏感EOC患者[6.0（6.6）mg/dL vs 2.8（3.8）mg/dL; P <0.001]。国际妇产科医师联合会较高的分期（P < 0.001）、术后残留肿瘤块（P <0.001）、肿瘤分级（P = 0.001）、血清CA 125（P = 0.03）和血清CRP（P = 0.001）与总生存率独立相关。血清CRP <1 mg/dL者5年生存率为82%，明显高于58.5%（P < 0.001）。
Purpose: To evaluate serum C-reactive protein (CRP) as prognostic variable in patients with epithelial ovarian cancer (EOC).Experimental Design: In a multicenter study, preoperative serum CRP was evaluated in 623 patients with EOC. Results were correlated with clinical data.Results: Mean (SD) preoperative serum CRP was 3.6 (4.8) mg/dL. Serum CRP was significantly associated with International Federation of Gynecologists and Obstetricians stage (P < 0.001) and postoperative residual tumor mass (P < 0.001) but not with histologic grade (P = 0.1) and type (P = 0.7), patients' age (Pearson's correlation coefficient = 0.05; P = 0.2), and serum CA 125 (Pearson's correlation coefficient = 0.02; P = 0.6). Patients with platinum-resistant EOC had significantly higher CRP serum levels compared with patients with platinum-sensitive EOC [6.0 (6.6) mg/dL versus 2.8 (3.8) mg/dL; P < .001]. Higher International Federation of Gynecologists and Obstetricians stage (P < 0.001), presence of postoperative residual tumor mass (P < 0.001), tumor grade (P = 0.001), serum CA 125 (P = 0.03), and serum CRP (P = 0.001) were independently associated with overall survival. Patients with serum CRP 1 mg/dL had an overall 5-year survival of 82% versus 58.5% (P < 0.001).Conclusion: Serum CRP can be seen as a novel, widely available independent prognostic variable of ovarian cancer.