Alzheimer Disease Assessment Scale: Useful for Both Early Detection and Staging of Dementia of the Alzheimer Type
Alzheimer Disease Assessment Scale: Useful for Both Early Detection and Staging of Dementia of the Alzheimer Type
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阿尔茨海默病评估量表：对于阿尔茨海默型痴呆的早期检测和分期都有用
DOI：
10.1097/00002093-199206020-00004
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发表时间：
1992
影响因子：
2.1
通讯作者：
R. Becker
中科院分区：
文献类型：
--
作者：
R. Zec;E. Landreth;S. Vicari;Eleanor Feldman;J. Belman;Alicia Andrise;R. Robbs;Vinod Kumar;R. Becker
阿尔茨海默病评估量表 (ADAS) 对 61 名阿尔茨海默型痴呆 (DAT) 患者和 52 名老年对照进行了评估。 DAT组根据简易精神状态检查的分数被细分为不同严重程度的痴呆：极轻度（≥24）、轻度（20至23）、中度（10至19）和重度（0至9）。 ADAS 认知分量表上四种痴呆级别的平均得分（极轻度 = 23.1 ± 7.7、轻度 = 22.9 ± 8.9、中度 = 38.6 ± 9.8、重度 = 54.8 ± 7.6）彼此之间存在统计学差异（p < 0.0001，极轻度与轻度除外），并且显着低于老年对照组的得分（5.5 ± 2.7，p < 0.0001，方差分析）。此外，ADAS 认知分量表在区分阿尔茨海默病患者和老年对照方面非常有效。当使用高于对照组平均值 2 个标准差的截止分数时，ADAS 认知评分正确分类了 100% 的极轻度组、91% 的整个轻度组以及 100% 的中度和重度组。年龄和教育程度对 ADAS 认知评分的影响很小。 ADAS 是一项有价值的筛查测试，仅需 30 分钟即可完成，并且可用于 DAT 的早期检测和分期。
The Alzheimer Disease Assessment Scale (ADAS) was administered to 61 patients with dementia of the Alzheimer type (DAT) and 52 elderly controls. The DAT group was subdivided into different severity levels of dementia based on scores from the Mini-Mental State Exam: very mild (≥24), mild (20 to 23), moderate (10 to 19), and severe (0 to 9). The mean scores on the ADAS Cognitive subscale for the four levels of dementia (very mild = 23.1 ± 7.7, mild = 22.9 ± 8.9, moderate = 38.6 ± 9.8, severe = 54.8 ± 7.6) were statistically different from one another (p < 0.0001, except very mild vs. mild) and were significantly worse than the scores of the elderly control group (5.5 ± 2.7, p < 0.0001, ANOVA). Furthermore, the ADAS Cognitive subscale was highly effective in discriminating individual Alzheimer patients from elderly controls. The ADAS Cognitive score correctly classified 100% of the very mild group, 91% of the entire mild group, and 100% of the moderate and severe groups when a cutoff score of 2 SDs above the control group mean was used. Age and education had only minimal effects on the ADAS Cognitive score. The ADAS is a valuable screening test that only takes 30 min to administer and has utility in both early detection and staging of DAT.