Assessing Depression and Cognitive Impairment Following Stroke and Neurotrauma: Behavioral Methods for Quantifying Impairment and Functional Recovery.
Assessing Depression and Cognitive Impairment Following Stroke and Neurotrauma: Behavioral Methods for Quantifying Impairment and Functional Recovery.
复制标题
评估中风和神经创伤后的抑郁和认知障碍：量化损伤和功能恢复的行为方法。
DOI：
10.1007/978-1-0716-2926-0_20
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Sohrabji,Farida
中科院分区：
文献类型：
--
作者：
deSouza,KariennA;Hook,Michelle;Sohrabji,Farida
Rodent models of stroke and neural injury are reliable and useful tools for testing new interventions and therapeutics. In addition to physical (motor) impairment, cognitive deficits and depressive behaviors are often observed due to neurotrauma. Proper experimental design of pre- and post-assessments of these behaviors that reduce or minimize the confounding effects of motor impairment are essential for determining markers of progression of impairment or recovery. This chapter provides step-by-step laboratory protocols for assessing cognition using the Barnes maze and the novel object recognition test (NORT) and depressive-like behaviors using the sucrose preference test, the three-chambered sociability approach test, and the burrowing test.
