Two cases of multiple hormone‐producing small cell carcinoma of the lung. Coexistence of tumor ADH, ACTH, and β‐MSH
Two cases of multiple hormone‐producing small cell carcinoma of the lung. Coexistence of tumor ADH, ACTH, and β‐MSH
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肿瘤ADH、ACTH和β-MSH共存的多种产生激素的小细胞癌2例。
DOI：
10.1002/1097-0142(197612)38:6
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发表时间：
1976
期刊：
影响因子：
6.2
通讯作者：
M. Itoh
中科院分区：
文献类型：
--
作者：
Y. Hirata;S. Matsukura;H. Imura;T. Yakura;Satoshi Ihjima;Chiaki Nagase;M. Itoh
据报道，有两例与多种激素异位产生相关的小细胞肺癌病例。两种肿瘤均含有大量的抗利尿激素 (ADH)、促肾上腺皮质激素 (ACTH) 和 β-MSH。人们发现这些异位激素的生物学、免疫学和凝胶色谱特性与垂体来源的激素非常相似。两例患者的临床表现均以抗利尿激素（ADH）过度分泌的影响为主，即抗利尿激素分泌不当综合征（SIADH）。异位 ACTH-MSH 综合征的临床表现很少。这些数据表明，在小细胞（燕麦细胞）肺癌中，产生多种激素而没有临床上明显的激素过量后遗症的情况并不少见。
Two cases of small cell carcinoma of the lung associated with the ectopic production of multiple hormones are reported. Both tumors were shown to contain significant amounts of ADH, ACTH, and β‐MSH. Biologic, immunologic, and gel chromatographic properties of these ectopic hormones were found to be very similar to those of pituitary origin. The effect of excessive secretion of antidiuretic hormone (ADH) dominated the clinical manifestations in both cases, i.e., syndrome of inappropriate secretion of ADH (SIADH). The clinical manifestations of the ectopic ACTH‐MSH syndrome were minimal. These data suggest that multiple hormone production without clinically overt sequelae of excess hormone is not uncommon in small cell (oat cell) carcinoma of the lung.