Tomographic Imaging by a Si/CdTe Compton Camera for 111In and 131I Radionuclides
Tomographic Imaging by a Si/CdTe Compton Camera for 111In and 131I Radionuclides
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使用 Si/CdTe 康普顿相机对 111In 和 131I 放射性核素进行层析成像
DOI：
10.1109/trpms.2021.3104665
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发表时间：
2022
影响因子：
4.4
通讯作者：
Moriyama Fumiki
中科院分区：
文献类型：
--
作者：
Yabu Goro;Yoneda Hiroki;Orita Tadashi;Takeda Shin'ichiro;Caradonna Pietro;Takahashi Tadayuki;Watanabe Shin;Moriyama Fumiki
核医学中常用的放射性核素层析成像，如111in（171和245 keV）和131i (364 keV)，在医学应用和小动物成像方面有很高的需求。Si/CdTe康普顿相机具有高角度和高能量分辨率，是一种特别有前途的探测器，可以将成像的能量覆盖范围扩展到涵盖这些放射性核素发出的伽马射线。在这里，我们通过使用由多个直径为2.7 mm的111in和131i球状溶液组成的3-D幻影，在距离为41 mm的地方进行实验，迈出了短距离成像的第一步。采用简单反投影（SBP）方法，以11.5 mm和9.0 mm （FWHM）的空间分辨率再现了111in和131i的辐射源位置。我们发现列表模式最大似然期望最大化（LM-MLEM）方法提供了更好的分辨率，分别为4.0和2.7 mm （FWHM）。我们解决了一个四面体结构的源位置，源到源的分离为28毫米。这些发现表明康普顿照相机具有近距离成像400 keV以下能量范围内放射性同位素分布的潜力。
Tomographic imaging with radionuclides commonly used in nuclear medicine, such as111In (171 and 245 keV) and131I (364 keV), is in high demand for medical applications and small animal imaging. The Si/CdTe Compton camera with its high angular and high energy resolutions is an especially promising detector to extend the energy coverage for imaging to the range that covers gamma ray emitted from these radionuclides. Here, we take the first steps toward short-distance imaging by conducting experiments using 3-D phantoms composed of multiple sphere-like solutions of111In and131I with a diameter of 2.7 mm, placed at a distance of 41 mm. Using simple back-projection (SBP) methods, the positions of the sources are reproduced with a spatial resolution of 11.5 and 9.0 mm (FWHM) for111In and131I, respectively. We found that a list-mode maximum-likelihood expectation maximization (LM-MLEM) method gives a better resolution of 4.0 and 2.7 mm (FWHM). We resolve source positions of a tetrahedron structure with a source-to-source separation of 28 mm. These findings demonstrate that Compton Cameras have the potential of close-distance imaging of radioisotopes distributions in the energy range below 400 keV.