Ozone: A Potential Oxidant for COVID-19 Virus (SARS-CoV-2)
Ozone: A Potential Oxidant for COVID-19 Virus (SARS-CoV-2)
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DOI：
10.1080/01919512.2020.1795614
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发表时间：
2020-07-28
影响因子：
2.7
通讯作者：
Tizaoui, Chedly
中科院分区：
文献类型：
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作者：
Tizaoui, Chedly
目前，没有药物显示出治疗由SARS-CoV-2病毒引起的持续大流行COVID-19的有效性。作为一种强氧化剂，臭氧对水中、表面和气溶胶中的大多数细菌和病毒都是致命的。臭氧还被成功地用于治疗几种病毒性疾病，如埃博拉病毒和艾滋病毒肝炎B和C。利用分子模拟，这项研究评估了臭氧对SARS-CoV-2结构中代表性关键分子的反应性。结果表明，臭氧能够攻击病毒刺突和包膜的蛋白质和脂质，特别是氨基酸色氨酸、甲硫氨酸和半胱氨酸，以及脂肪酸、花生四烯酸、亚油酸和油酸。臭氧还攻击刺突蛋白亚基1和2的N-糖肽，尽管反应性较低。破坏SARS-CoV-2的结构可以使病毒灭活，这表明臭氧可能是对抗COVID-19病毒的有效氧化剂。如果使用不当，臭氧是有毒的，必须避免与呼吸道接触。
Currently, no medicine has demonstrated efficacy in treating the ongoing pandemic COVID-19 caused by SARS-CoV-2 virus. Being a potent oxidant, ozone is lethal against most bacteria and viruses found in water, or on surfaces and aerosols. Ozone has also been successfully used to treat several viral diseases such as Ebola and HIV Hepatitis B and C. Using molecular modeling, this study evaluated the reactivity of ozone toward representative key molecules in the structure of SARS-CoV-2. The results show that ozone is able to attack the proteins and lipids of the virus's spikes and envelope, particularly the amino acids tryptophan, methionine and cysteine, and the fatty acids, arachidonic acid, linoleic acid, and oleic acid. Ozone also attacks the N-glycopeptides of the spike protein subunits 1 and 2, though at lower reactivity. Disruption of the structure of SARS-CoV-2 could inactivate the virus, suggesting that ozone could be an effective oxidant against COVID-19 virus. If incorrectly applied, ozone is toxic and contact with the respiratory tract must be avoided.