Identification of the Xenopus laevis cDNA for EXT1: a phylogenetic perspective.
Identification of the Xenopus laevis cDNA for EXT1: a phylogenetic perspective.
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非洲爪蟾 EXT1 cDNA 的鉴定：系统发育的角度。
DOI：
10.1080/10425170290029990
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Wells,DE
中科院分区：
文献类型：
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作者：
Hill,AL;Brown,N;Hill,MS;Wells,DE
EXT基因家族参与硫酸乙酰肝素分子的发育重要生物合成。EXT家族的成员在果蝇的原肠胚形成、翅膀形成和脊椎动物的适当骨发育中具有已证实的作用。EXT家族成员已经从几个不同的物种中分离出来。我们在这里报告，分离的第一个非洲爪蟾EXT1家族成员，并讨论这个基因家族的进化起源。
The EXT family of genes is involved in the developmentally important biosynthesis of heparan sulfate molecules. Members of the EXT family have a demonstrated role in gastrulation, wing formation in flies, and proper bone development in vertebrates. EXT family members have been isolated from several phylogenetically diverse species. We report here, the isolation of the first Xenopus laevis EXT1 family member and discuss the evolutionary origins of this gene family.